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Literature summary for 1.13.11.31 extracted from

  • Ho, X.L.; Liu, J.J.; Loke, W.M.
    Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults - a randomized-controlled trial (2016), Free Radic. Res., 50, 1396-1407 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + O2 Homo sapiens LTA4 can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4) lipoxin A4
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P18054
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-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + O2 LTA4 can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4) Homo sapiens lipoxin A4
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 ?

Synonyms

Synonyms Comment Organism
12-lipoxygenase
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 Homo sapiens
12-LO
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 Homo sapiens
platelet 12-lipoxygenase
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the 5-LO-derived leukotriene A4, LTA4, can be converted by the action of platelet 12-lipoxygenase (12-LO) to lipoxin A4 (LXA4), which exerts potent anti-inflammatory activities and vascular bed-dependent vasodilatory actions. Dietary plant sterols, beta-sitosterol, campesterol, and stigmasterol, in the combination used, can alleviate lipid peroxidation and inflammatory events in vivo. These effects are possibly exerted via the modulation of myeloperoxidase, 5-lipoxygenase, and 12-lipoxygenase activities Homo sapiens