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Literature summary for 1.13.11.31 extracted from

  • Halade, G.V.; Kain, V.; Ingle, K.A.; Prabhu, S.D.
    Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing (2017), Am. J. Physiol. Heart Circ. Physiol., 313, H89-H102 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Mus musculus C57BL/6J
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Mus musculus
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leukocyte
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 Mus musculus
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macrophage
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 Mus musculus
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neutrophil
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 Mus musculus
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Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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 Mus musculus
12/15-LOX
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 Mus musculus

General Information

General Information Comment Organism
malfunction deletion of 12/15-LOX in mice leads to increased cytochrome P450-derived bioactive lipid mediator epoxyeicosatrienoic acids, i.e. 11,12-EpETrE and 14,15-EpETrE, which are further enhanced by acute PUFA intake post-MI. Macrophage density is decreased in wild-type + PUFA and 12/15-LOX-/- mice compared with their respective standard diet-fed wild-type controls at day 5 post-MI. 12/15-LOX-/- + PUFA mice display an increased expression of chemokine (C-C motif) ligand 2 and reparative macrophages markers (Ym-1, Mrc-1, and Arg-1) in the infarcted area. Furthermore, 12/15-LOX-/- mice, with or without PUFA, show reduced collagen deposition at day 5 post-MI compared with wild-type mice. In conclusion, deletion of 12/15-LOX and short-term exposure of PUFA promote leukocyte clearance, thereby limiting cardiac remodeling and promoting an effective resolution of inflammation Mus musculus
physiological function the metabolic transformation of fatty acids to form oxylipids using 12/15-lipoxygenase (LOX) can promote either resolving or nonresolving inflammation. 12/15-LOX interacts with polyunsaturated fatty acids (PUFA) in postmyocardial infarction (post-MI) healing, mechanism, overview Mus musculus