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Literature summary for 1.13.11.31 extracted from
- Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes (2008), Neurochem. Int., 53, 220-229.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dihydroceramide has no effect | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | induction of pro-carcinogenic 12-LOX pathway by an anticancer ceramide, which may be relevant to cancer biologists studying drug resistant tumors and devising potent anticancer therapeutic strategies to treat drug resistant tumors. Induction of 12-LOX pathway by ceramide may have implications in understanding pathophysiology of neurodegenerative diseases involving reactive oxygen species generation and inflammation | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| baicalein | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Rattus norvegicus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 12-lipoxygenase | - |
Rattus norvegicus |
| 12-LOX | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | ceramide increases mRNA and protein expression, and activity of 12-LOX | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | possibility of 12-LOX involvement in ceramide-mediated generation of reactive oxygen species and cellular oxidative stress | Rattus norvegicus |
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Release 2023.1 (January 2023)
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