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Literature summary for 1.13.11.31 extracted from

  • Chen, F.L.; Wang, X.Z.; Li, J.Y.; Yu, J.P.; Huang, C.Y.; Chen, Z.X.
    12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway (2008), Digest. Dis. Sci., 53, 181-187.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
baicalein
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arachidonate + O2 Homo sapiens
-
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (12S)-hydroxyeicosatetraenoate, which inhibits apoptosis in gastric cancer and activates ERK phosphorylation and the ERK1/2 signalling pathway, 12-LOX activates protein kinase C in AGS cells, overview ?
additional information Homo sapiens 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
Homo sapiens
-
carcinoma cell 12-LOX is overexpressed in a variety of human tumors Homo sapiens
-
gastric cancer cell 12-LOX overexpression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
?
arachidonate + O2
-
Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate further metabolized to (12S)-hydroxyeicosatetraenoate, which inhibits apoptosis in gastric cancer and activates ERK phosphorylation and the ERK1/2 signalling pathway, 12-LOX activates protein kinase C in AGS cells, overview ?
additional information 12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 60000-80000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
12-lipoxygenase
-
Homo sapiens
12-LOX
-
Homo sapiens