Any feedback?
Literature summary for 1.13.11.31 extracted from
- Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase (2003), Biochemistry, 42, 5236-5243.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| severe autoinactivation is observed at high substrate concentrations if the substrate is not HPLC-purified and stored at -80°C | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 7 | - |
O2 | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
| linoleic acid + O2 | 4% of the activity with arachidonate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 12-hLO | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.5 | - |
arachidonate | pH 7.5, 15°C | Homo sapiens | |
| 13.1 | - |
O2 | - |
Homo sapiens | |
| 17.8 | - |
arachidonate | pH 7.5, 30°C | Homo sapiens | |
| 46 | - |
arachidonate | pH 7.5, 45°C | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
