Literature summary for 1.13.11.31 extracted from

Richards, K.M.; Moody, J.S.; Marnett, L.J.
Mechanism of Inhibition of Porcine Leukocyte 12-Lipoxygenase by the Isoform-Specific Inhibitor 4-(2-Oxapentadeca-4-yne)phenylpropanoic Acid (1999), Biochemistry, 38, 16529-16538.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(2-oxapentadeca-4-yne)phenylpropanoic acid	shows the oxidation of the inactive ferrous enzyme to the active ferric enzyme and competes with arachidonic acid for the ferric enzyme	Sus scrofa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	enzyme contains iron	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid	Sus scrofa	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?

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Release 2023.1 (January 2023)