Literature summary for 1.13.11.27 extracted from

Lin, H.Y.; Yang, J.F.; Wang, D.W.; Hao, G.F.; Dong, J.Q.; Wang, Y.X.; Yang, W.C.; Wu, J.W.; Zhan, C.G.; Yang, G.F.
Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition enzyme kinetics, X-ray crystallography and computational simulations (2019), FEBS J., 286, 975-990 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structures in complex with inhibitors nitisinone, sulcotrione and mesotrione. A conformational change of Phe428 is found at the C-terminal alpha-helix in the inhibitor-bound structures and the inhibition kinetics of drugs are related to steric hindrance of Phe428	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
mesotrione	slow binding inhibitor, not inhibitory to homogentisate 1,2-dioxygenase	Arabidopsis thaliana
nitisinone	i.e. 2-[2-nitro-4-(trifluoromethyl) benzoyl]-1,3-cyclohexanedione, slow binding inhibitor, not inhibitory to homogentisate 1,2-dioxygenase	Arabidopsis thaliana
sulcotrione	slow binding inhibitor, not inhibitory to homogentisate 1,2-dioxygenase	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	P93836	-	-

Synonyms

Synonyms	Comment	Organism
HPD	-	Arabidopsis thaliana
HPPD	-	Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000096	-	sulcotrione	pH 7, 25°C	Arabidopsis thaliana
0.0000046	-	mesotrione	pH 7, 25°C	Arabidopsis thaliana
0.0000064	-	nitisinone	pH 7, 25°C	Arabidopsis thaliana

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Release 2023.1 (January 2023)