Literature summary for 1.13.11.27 extracted from

Qiao, Y.; Wang, J.; Wang, H.; Chai, B.; Rao, C.; Chen, X.; Du, S.
4-Hydroxyphenylpyruvate dioxygenase thermolability is responsible for temperature-dependent melanogenesis in Aeromonas salmonicida subsp. salmonicida (2019), Appl. Environ. Microbiol., 85, e01926 .

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Protein Variants

Protein Variants	Comment	Organism
L119P	mutation increases the thermostability of the enzyme	Aeromonas salmonicida subsp. salmonicida
P103Q	mutation increases the thermostability of the enzyme	Aeromonas salmonicida subsp. salmonicida
P103Q/L119P	mutation enables recombinant Escherichia coli strains to form melanin at 30°C and 37°C	Aeromonas salmonicida subsp. salmonicida
P117L	Escherichia coli cells expressing the mutant form pigment at all tested temperatures	Aeromonas salmonicida subsp. salmonicida
Q101P	Escherichia coli cells expressing the mutant fail to form pigment at all 37°C	Aeromonas salmonicida subsp. salmonicida
Q101P/P117L	Escherichia coli cells expressing the mutant form pigment at all tested temperatures	Aeromonas salmonicida subsp. salmonicida
S18T	mutation increases the thermostability of the enzyme	Aeromonas salmonicida subsp. salmonicida
S18T/L119P	mutation enables recombinant Escherichia coli strains to form melanin at 30°C	Aeromonas salmonicida subsp. salmonicida
S18T/P103Q	mutation enables recombinant Escherichia coli strains to form melanin at 30°C and 37°C	Aeromonas salmonicida subsp. salmonicida
S18T/P103Q/L119P	mutation enables recombinant Escherichia coli strains to form melanin at 30°C and 37°C	Aeromonas salmonicida subsp. salmonicida
T16S	Escherichia coli cells expressing the mutant form pigment at all tested temperatures	Aeromonas salmonicida subsp. salmonicida
T16S/P117L	Escherichia coli cells expressing the mutant form pigment at all tested temperatures	Aeromonas salmonicida subsp. salmonicida
T16S/Q101P	Escherichia coli cells expressing the mutant form pigment at all tested temperatures	Aeromonas salmonicida subsp. salmonicida
T16S/Q101P/P117L	Escherichia coli cells expressing the mutant completely lose melanin formation ability at 30°C and 37°C	Aeromonas salmonicida subsp. salmonicida

Organism

Organism	UniProt	Comment	Textmining
Aeromonas salmonicida subsp. salmonicida	A0A6N4CSS6	-	-

Synonyms

Synonyms	Comment	Organism
ASJ32_19370	-	Aeromonas salmonicida subsp. salmonicida
HPPD	-	Aeromonas salmonicida subsp. salmonicida

General Information

General Information	Comment	Organism
physiological function	heterologous expression results in thermosensitive pigmentation in Escherichia coli. The thermolability of HppD is responsible for the temperature-dependent melanization of Aeromonas salmonicida subsp. salmonicida	Aeromonas salmonicida subsp. salmonicida

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Release 2023.1 (January 2023)