Crystallization (Comment) | Organism |
---|---|
crystal structure analysis of HPPD-Fe(II)-acetate complex, PDB ID 1CJX | Pseudomonas fluorescens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe | Fe(II), Fe(III), and Fe(IV) during oxygenation and hydroxylation, overview. The iron ion is coordinated by a His-His-Glu triad, structure of HPPD-Fe(II)-acetate complex, overview | Pseudomonas fluorescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | Pseudomonas fluorescens | - |
homogentisate + CO2 | - |
? | |
4-hydroxyphenylpyruvate + O2 | Pseudomonas fluorescens ATCC 13525 | - |
homogentisate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas fluorescens | - |
- |
- |
Pseudomonas fluorescens ATCC 13525 | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 | reaction mechanism, quantum mechanics/molecular mechanics calculations and simulations, detailed overview | Pseudomonas fluorescens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxyphenylpyruvate + O2 | - |
Pseudomonas fluorescens | homogentisate + CO2 | - |
? | |
4-hydroxyphenylpyruvate + O2 | - |
Pseudomonas fluorescens ATCC 13525 | homogentisate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme structure comparisons, structure homology modeling, overview | Pseudomonas fluorescens |
Synonyms | Comment | Organism |
---|---|---|
HPPD | - |
Pseudomonas fluorescens |
General Information | Comment | Organism |
---|---|---|
metabolism | suggested hydroxylation mechanisms for HMS and HPPD and pathways leading to alternative products: oxepinone and quinolacetate | Pseudomonas fluorescens |
additional information | molecular dynamics simulations are performed for the HPPD-Fe(IV)=O-hydroxyphenylacetate complex in order to obtain a reliable starting structure for quantum mechanics/molecular mechanics calculations of ring hydroxylation and coupled rearrangement reactions catalyzed by the enzyme HPPD, structure of HPPD-Fe(II)-acetate complex, structure homology modeling, overview | Pseudomonas fluorescens |