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Literature summary for 1.13.11.20 extracted from

  • Sallmann, M.; Kumar, S.; Chernev, P.; Nehrkorn, J.; Schnegg, A.; Kumar, D.; Dau, H.; Limberg, C.; de Visser, S.P.
    Structure and mechanism leading to formation of the cysteine sulfinate product complex of a biomimetic cysteine dioxygenase model (2015), Chemistry, 21, 7470-7479 .
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ non-heme iron enzyme. The enzyme contains an iron active site with an unusual 3-His ligation to the protein, which contrasts with the structural features of common nonheme iron dioxygenases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + O2 Homo sapiens
-
3-sulfinoalanine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16878
-
-

Reaction

Reaction Comment Organism Reaction ID
L-cysteine + O2 = 3-sulfinoalanine reaction mechanism of cysteine oxygenation by CDO enzymes and reactivity of [TpMe,PhFe(CysOEt)] towards O2, detailed quantum mechanics/molecular mechanics calculations, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + O2
-
Homo sapiens 3-sulfinoalanine
-
?
L-cysteine + O2 structure of the sulfinato complex, overview Homo sapiens 3-sulfinoalanine
-
?
additional information prediction of a h2-O,O-binding mode for synthetic as well as the natural enzyme, modeling of the cysteine sulfinic product complex in the active site Homo sapiens ?
-
?

General Information

General Information Comment Organism
additional information structure and mechanism leading to formation of the cysteine sulfinate product complex of a biomimetic cysteine dioxygenase model, i.e. trispyrazolylborato iron(II) cysteinato complex, overview. The enzyme contains an iron active site with an unusual 3-His ligation to the protein, which contrasts with the structural features of common non-heme iron dioxygenases Homo sapiens
physiological function the enzyme is involved in the metabolism of L-cysteine in the body Homo sapiens