Protein Variants | Comment | Organism |
---|---|---|
additional information | Vanin 1-/- and +/+ mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
(C57/B6), wild type and Vanin 1-/- and +/+ mice | - |
Rattus norvegicus | - |
Sprague-Dawley, rats switched from a high protein diet to a low protein diet or to a low protein diet supplemented with cysteamine do not demonstrate a change in tissue cysteamine dioxygenase activity over the course of 10 h. | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | Cysteamine levels in plasma of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have no markedly elevated levels of hypotaurine in plasma. | Rattus norvegicus | - |
brain | Cysteamine levels in brain of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in brain. | Rattus norvegicus | - |
brain | hypotaurine is not in brain of either Vanin-1 (+/+) or Vanin-1 (-/-) mice that had been fed a non-purified rodent diet. | Mus musculus | - |
kidney | higher activity than in rat kidney. Hypotaurine is measurable in kidney, but levels are significantly higher in kidneys of the knock-out mice compared to wild-type mice. | Mus musculus | - |
kidney | lower activity than in mice kidney. Cysteamine levels in kidney of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in kidney. | Rattus norvegicus | - |
liver | higher activity than in rat liver. hypotaurine is not in liver of either Vanin-1 (+/+) or Vanin-1 (-/-) mice that had been fed a non-purified rodent diet. | Mus musculus | - |
liver | lower activity than in mice liver. Cysteamine levels in liver of rats fed the cysteamine supplemented diet are significantly higher than those in tissues of rats fed basal diet. Rats fed the cysteamine-supplemented diet have markedly elevated levels of hypotaurine in liver. | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000021 | - |
substrate: hypertaurine, kidney, activity is lower than in mice kidney | Rattus norvegicus |
0.000026 | - |
substrate: hypertaurine, liver, activity is lower than in mice liver | Rattus norvegicus |
0.000037 | - |
substrate: hypertaurine, kidney, higher activity in mice kidney than in rat kidney | Mus musculus |
0.000062 | - |
substrate: hypertaurine, brain | Rattus norvegicus |
0.000091 | - |
substrate: hypertaurine, liver, higher activity in mice liver than in rat liver | Mus musculus |