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Literature summary for 1.13.11.15 extracted from

  • Que, L.; Widom, J.; Crawford, R.L.
    3,4-Dihydroxyphenylacetate 2,3-dioxygenase. A manganese(II) dioxygenase from Bacillus brevis (1981), J. Biol. Chem., 256, 10941-10944.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Brevibacillus brevis
3,4-dihydroxybenzoate
-
Brevibacillus brevis
3,4-dihydroxycinnamate
-
Brevibacillus brevis
3,4-Dihydroxyphenylpropionate
-
Brevibacillus brevis
4-methylcatechol
-
Brevibacillus brevis
4-nitrocatechol
-
Brevibacillus brevis
8-hydroxyquinoline
-
Brevibacillus brevis
catechol
-
Brevibacillus brevis
m-hydroxyphenylacetate
-
Brevibacillus brevis
p-hydroxyphenylacetate
-
Brevibacillus brevis
PCMB
-
Brevibacillus brevis

Metals/Ions

Metals/Ions Comment Organism Structure
Iron the enzyme contains 0.04-0.2 gatom of iron Brevibacillus brevis
Manganese approximately 2 gatom of manganese per mol of protein Brevibacillus brevis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
4 * 36000, SDS-PAGE Brevibacillus brevis
120000
-
equilibrium sedimentation Brevibacillus brevis
140000
-
gel filtration Brevibacillus brevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxyphenylacetate + O2 Brevibacillus brevis enzyme catalyzes the estradiol cleavage of catechols 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
?

Organism

Organism UniProt Comment Textmining
Brevibacillus brevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Brevibacillus brevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxymandelate + O2 14% of the activity with 3,4-dihydroxyphenylacetate Brevibacillus brevis ?
-
?
3,4-dihydroxyphenylacetate + O2
-
Brevibacillus brevis 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
?
3,4-dihydroxyphenylacetate + O2 enzyme catalyzes the estradiol cleavage of catechols Brevibacillus brevis 2-hydroxy-5-carboxymethylmuconate semialdehyde
-
?
3,4-dihydroxyphenylpropionate + O2 5% of the activity with 3,4-dihydroxyphenylacetate Brevibacillus brevis 2-hydroxy-5-carboxyethylmuconate semialdehyde
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 36000, SDS-PAGE Brevibacillus brevis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Brevibacillus brevis

pH Stability

pH Stability pH Stability Maximum Comment Organism
7
-
most stable at Brevibacillus brevis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.27
-
m-hydroxyphenylacetate
-
Brevibacillus brevis
0.3
-
3,4-dihydroxycinnamate
-
Brevibacillus brevis
0.5
-
4-nitrocatechol
-
Brevibacillus brevis
1
-
3,4-Dihydroxyphenylpropionate
-
Brevibacillus brevis
1.5
-
4-methylcatechol
-
Brevibacillus brevis
1.8
-
p-hydroxyphenylacetate
-
Brevibacillus brevis
2.3
-
3,4-dihydroxybenzoate
-
Brevibacillus brevis
3.8
-
catechol
-
Brevibacillus brevis