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Literature summary for 1.12.2.1 extracted from

  • Topin, J.; Rousset, M.; Antonczak, S.; Golebiowski, J.
    Kinetics and thermodynamics of gas diffusion in a NiFe hydrogenase (2012), Proteins, 80, 677-682.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
V74Q while wild-type tends to attract O2 molecules close to the active site, the V74Q mutant favors the localization of O2 about 20 A away from it. In the mutant, the glutamine residue produces an energy barrier height higher than the one found when a valine is present as in wild-type. In the V74Q mutant, the enzyme inhibition by O2 is lowered from both a kinetic and a thermodynamic point of view with respect to the wild-type enzyme Solidesulfovibrio fructosivorans

Inhibitors

Inhibitors Comment Organism Structure
O2 wild-type tends to attract O2 molecules close to the active site Solidesulfovibrio fructosivorans

Organism

Organism UniProt Comment Textmining
Solidesulfovibrio fructosivorans P18187 small subunit
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