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Literature summary for 1.11.1.9 extracted from

  • Franco, J.L.; Posser, T.; Dunkley, P.R.; Dickson, P.W.; Mattos, J.J.; Martins, R.; Bainy, A.C.; Marques, M.R.; Dafre, A.L.; Farina, M.
    Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase (2009), Free Radic. Biol. Med., 47, 449-457.
    View publication on PubMed
Search for more literature for 1.11.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tert-butyl hydroperoxide + 2 GSH
-
 Mus musculus tert-butyl alcohol + GSSG + H2O
-
 ?
tert-butyl hydroperoxide + 2 GSH
-
 Homo sapiens tert-butyl alcohol + GSSG + H2O
-
 ?

Synonyms

Synonyms Comment Organism
GPX
-
 Mus musculus
GPX
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus adult male Swiss mice treated with 40 mg/ml methylmercury for 21 days show about 50% decrease in GPx activity in the brain down

General Information

General Information Comment Organism
malfunction methylmercury neurotoxicity is associated with inhibition of glutathione peroxidase Mus musculus
malfunction methylmercury neurotoxicity is associated with inhibition of glutathione peroxidase Homo sapiens