Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hyperglycemia | increased GPX1 activity in rat VSM cell. When cells are exposed to high glucose (25 mM) for 48 h, GPX1 activity is 2.5fold greater than in cells grown in normal glucose (5 mM), while the GPX1 expression levels are the same | Rattus norvegicus | |
additional information | increasing the cellular O-GlcNAcylation level enhances GPX1 activity | Rattus norvegicus | |
additional information | injection of the O-GlcNAcase inhibitor 1,2-dideoxy-2'-propyl-alpha-D-glucopyranoso-[2,1-d]-DELTA2'-thiazoline increases GPX1 activity in the mouse liver | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Rattus norvegicus |
expression constructs encoding full-length (1-201) and C-terminal deletion (1-100) versions of human GPX1 (Sec47Cys) for overexpression in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | full-length (1-201) and C-terminal deletion (1-100) versions of human GPX1 (Sec47Cys), full-length FLAG-GPX1 is modified with O-GlcNAc, while the truncated FLAG-GPX1 is not, despite the fact that truncated GPX1 is still able to bind OGT. O-GlcNAcylation occurs on the C-terminal half of GPX1 | Homo sapiens |
additional information | GPX1 modified with O-GlcNAc on its C-terminus, cell lysate of VSMCs treated with the O-GlcNAcase inhibitor PUGNAc | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | selenium-containing enzyme | Mus musculus | |
selenium | selenium-containing enzyme | Homo sapiens | |
selenium | selenium-containing enzyme | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
B6C3F1/J mice, mating C57BL/6J female mice to C3H/HeJ male mice | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
muscle | vascular smooth muscles cell | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
H2O2 + GSH | instead of tert-butyl hydroperoxide | Mus musculus | H2O + GSSG | - |
? | |
tert-butyl hydroperoxide + 2 GSH | - |
Homo sapiens | tert-butyl alcohol + GSSG + H2O | - |
? | |
tert-butyl hydroperoxide + 2 GSH | - |
Rattus norvegicus | tert-butyl alcohol + GSSG + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione peroxidase 1 | - |
Mus musculus |
glutathione peroxidase 1 | - |
Homo sapiens |
glutathione peroxidase 1 | - |
Rattus norvegicus |
GPX1 | - |
Mus musculus |
GPX1 | - |
Homo sapiens |
GPX1 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mus musculus |
25 | - |
assay at | Homo sapiens |
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mus musculus |
8 | - |
assay at | Homo sapiens |
8 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | anti-oxidant enzyme, essential for cell survival during oxidative stress | Mus musculus |
physiological function | anti-oxidant enzyme, essential for cell survival during oxidative stress | Homo sapiens |
physiological function | anti-oxidant enzyme, essential for cell survival during oxidative stress | Rattus norvegicus |