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Literature summary for 1.11.1.8 extracted from

  • Umeki, K.; Kawano, J.i.; Yamamoto, I.; Aratake, Y.; Kotani, T.
    Comparative analysis and characterization of mutated thyroid peroxidases with disturbance expressed on the cell surface (2004), Mol. Cell. Endocrinol., 223, 77-84.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
CHO-K1 cells introduced with mutated TPO-MRNA Homo sapiens

Protein Variants

Protein Variants Comment Organism
D574/L575del expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin Homo sapiens
G533C expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin Homo sapiens
G771R expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum wild-type enzyme and mutant enzymes G614A, G1687T, 1808-13del, C2083, G2401A Homo sapiens 5783
-
nuclear envelope wild-type enzyme and mutant enzymes G614A, G1687T, 1808-13del, C2083, G2401A Homo sapiens 5635
-
plasma membrane mutant enzymes D574/L575del, G553C and G771R expressed to varying degree on the plasma membrane. Mutant R665W shows no cell surface localization Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
thyroid peroxidase
-
Homo sapiens
TPQ
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Homo sapiens