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Literature summary for 1.11.1.21 extracted from

  • Rouse, D.A.; DeVito, J.A.; Li, Z.; Byer, H.; Morris, S.L.
    Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance (1996), Mol. Microbiol., 22, 583-592.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells and in Mycobacterium bovis BCG Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
A350T the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme Mycobacterium tuberculosis
D381G the mutant shows no catalase activity Mycobacterium tuberculosis
H108Q the mutant shows no catalase activity Mycobacterium tuberculosis
H270Q the mutant shows no catalase activity Mycobacterium tuberculosis
L148R the mutant shows no catalase activity Mycobacterium tuberculosis
L587M the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme Mycobacterium tuberculosis
N138S the KatG level of the mutant is 30% of wild type level, the mutant shows a 90% reduction in peroxidase activity Mycobacterium tuberculosis
R104L mutant with reduced enzymatic activity Mycobacterium tuberculosis
R463G the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme Mycobacterium tuberculosis
R463L the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme Mycobacterium tuberculosis
S140N the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme Mycobacterium tuberculosis
S315T the KatG level of the mutant is 90% of wild type level, the mutant shows 60% peroxidase and 40% catalase activity compared to the wild type enzyme Mycobacterium tuberculosis
T275P the mutant shows no catalase activity Mycobacterium tuberculosis
W321G the KatG level of the mutant is 40% of wild type level, the mutant shows a 70% reduction in peroxidase and catalase activities Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
Mycobacterium tuberculosis oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
?
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
Mycobacterium tuberculosis H37Rv oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
?
H2O2
-
Mycobacterium tuberculosis O2 + H2O
-
?
H2O2
-
Mycobacterium tuberculosis H37Rv O2 + H2O
-
?

Synonyms

Synonyms Comment Organism
KatG
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
heme
-
Mycobacterium tuberculosis