Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM109 cells and in Mycobacterium bovis BCG | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
A350T | the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme | Mycobacterium tuberculosis |
D381G | the mutant shows no catalase activity | Mycobacterium tuberculosis |
H108Q | the mutant shows no catalase activity | Mycobacterium tuberculosis |
H270Q | the mutant shows no catalase activity | Mycobacterium tuberculosis |
L148R | the mutant shows no catalase activity | Mycobacterium tuberculosis |
L587M | the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme | Mycobacterium tuberculosis |
N138S | the KatG level of the mutant is 30% of wild type level, the mutant shows a 90% reduction in peroxidase activity | Mycobacterium tuberculosis |
R104L | mutant with reduced enzymatic activity | Mycobacterium tuberculosis |
R463G | the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme | Mycobacterium tuberculosis |
R463L | the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme | Mycobacterium tuberculosis |
S140N | the catalase and peroxidase activities and isoniazid sensitivity is similar to the wild type enzyme | Mycobacterium tuberculosis |
S315T | the KatG level of the mutant is 90% of wild type level, the mutant shows 60% peroxidase and 40% catalase activity compared to the wild type enzyme | Mycobacterium tuberculosis |
T275P | the mutant shows no catalase activity | Mycobacterium tuberculosis |
W321G | the KatG level of the mutant is 40% of wild type level, the mutant shows a 70% reduction in peroxidase and catalase activities | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Mycobacterium tuberculosis | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? | |
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2 | - |
Mycobacterium tuberculosis H37Rv | oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O | - |
? | |
H2O2 | - |
Mycobacterium tuberculosis | O2 + H2O | - |
? | |
H2O2 | - |
Mycobacterium tuberculosis H37Rv | O2 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KatG | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mycobacterium tuberculosis |