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Literature summary for 1.11.1.21 extracted from

  • Bertrand, T.; Eady, N.A.; Jones, J.N.; Jesmin, J.N.; Nagy, J.M.; Jamart-Gregoire, B.; Raven, E.L.; Brown, K.A.
    Crystal structure of Mycobacterium tuberculosis catalase-peroxidase (2004), J. Biol. Chem., 279, 38991-38999.
    View publication on PubMed
Search for more literature for 1.11.1.21

Application

Application Comment Organism
medicine catalase-peroxidase activates the core anti-tuberculosis drug isoniazid Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain UM255 Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 4% (w/v) polyethylene glycol 3350 and 0.1 M sodium acetate (pH 4.6), at 20°C Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIE5
-
-
Mycobacterium tuberculosis H37Rv P9WIE5
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography, Superdex 200 gel filtration, and Resource Q column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
H2O2
-
 Mycobacterium tuberculosis H37Rv O2 + H2O
-
 ?
o-dianisidine + H2O2
-
 Mycobacterium tuberculosis oxidized o-dianisidine + H2O
-
 ?
o-dianisidine + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized o-dianisidine + H2O
-
 ?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
heme a heme-dependent enzyme Mycobacterium tuberculosis