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Literature summary for 1.11.1.12 extracted from

  • Ursini, F.; Maiorini, M.; Gregolin, C.
    The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (1985), Biochim. Biophys. Acta, 839, 62-70.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information interfacial character of the enzyme Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Se Se in selenol form Sus scrofa
Se 1 g-atom Se per mol protein Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
1 * 20000, SDS-PAGE Sus scrofa
23000
-
gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O tert-uni ping-pong mechanism Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
195.1
-
purified enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + cardiolipin
-
Sus scrofa ?
-
?
glutathione + cumene hydroperoxide
-
Sus scrofa ?
-
?
glutathione + dilinoleoyl phosphatidylcholine hydroperoxide and derivatives of dilinoyl phosphatidylcholine hydroperoxide Sus scrofa ?
-
?
glutathione + H2O2
-
Sus scrofa ?
-
?
glutathione + L-alpha-phosphatidylcholine hydroperoxide
-
Sus scrofa ?
-
?
glutathione + linoleic acid hydroperoxide
-
Sus scrofa ?
-
?
glutathione + lipid hydroperoxide
-
Sus scrofa glutathione disulfide + lipid + H2O
-
?
glutathione + phosphatidic acid hydroperoxide
-
Sus scrofa ?
-
?
glutathione + phosphatidylethanolamine hydroperoxide
-
Sus scrofa ?
-
?
glutathione + phosphatidylserine hydroperoxide
-
Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 23000, SDS-PAGE Sus scrofa
monomer 1 * 20000, SDS-PAGE Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Sus scrofa