Crystallization (Comment) | Organism |
---|---|
2.1 A resolution | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis | ? | - |
? | |
additional information | Homo sapiens | high QR2 activity might make individuals more susceptible to Parkinsons disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16083 | comparison with quinone reductase 1 | - |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | minimal expression | Homo sapiens | - |
erythrocyte | modest level | Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | high expression level | Homo sapiens | - |
additional information | no expression in placenta | Homo sapiens | - |
additional information | no expression in skeletal muscle | Mus musculus | - |
pancreas | minimal expression | Homo sapiens | - |
skeletal muscle | high expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | by deleting QR2 it seems that mice become increasingly susceptible to polycyclic aromatic hydrocarbon-induced skin carcinogenesis | Mus musculus | ? | - |
? | |
additional information | high QR2 activity might make individuals more susceptible to Parkinsons disease. By inhibiting QR2, it seems that anti-malarial compounds such as quinacrine favour the red blood cell oxidative stress leading to the death of the parasite | Homo sapiens | ? | - |
? | |
additional information | enzyme cannot use NADH or NADPH as reducing agent | Homo sapiens | ? | - |
? | |
N-benzyldihydronicotinamide + menadione | - |
Mus musculus | ? | - |
? | |
N-methyldihydronicotinamide + menadione | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NRH:quinone reductase 2 | - |
Mus musculus |
NRH:quinone reductase 2 | - |
Homo sapiens |
QR2 | - |
Mus musculus |
QR2 | - |
Homo sapiens |
quinone reductase 2 | - |
Mus musculus |
quinone reductase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | contains 1 FAD per monomer firmly bound to the enzyme through multiple interactions | Homo sapiens | |
additional information | enzyme cannot use NADH or NADPH as reducing agent | Homo sapiens |