Literature summary for 1.10.3.2 extracted from

Eisenman, H.C.; Mues, M.; Weber, S.E.; Frases, S.; Chaskes, S.; Gerfen, G.; Casadevall, A.
Cryptococcus neoformans laccase catalyses melanin synthesis from both D- and L-DOPA (2007), Microbiology, 153, 3954-3962.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DOPA + O2	Cryptococcus neoformans	the enzyme laccase catalyses the formation of melanin by oxidizing L-DOPA, initiating a series of presumably spontaneous reactions that ultimately leads to the polymerization of the pigment in the yeast cell wall. There, melanin protects the cell from a multitude of environmental and host assaults. Kinetics of dopachrome formation are similar for L- and D-DOPA	? + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Cryptococcus neoformans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DOPA + O2	-	Cryptococcus neoformans	? + H2O	-	?
DOPA + O2	the enzyme laccase catalyses the formation of melanin by oxidizing L-DOPA, initiating a series of presumably spontaneous reactions that ultimately leads to the polymerization of the pigment in the yeast cell wall. There, melanin protects the cell from a multitude of environmental and host assaults. Kinetics of dopachrome formation are similar for L- and D-DOPA	Cryptococcus neoformans	? + H2O	-	?

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Release 2023.1 (January 2023)