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Literature summary for 1.1.99.B9 extracted from

  • Xue, Y.; Zheng, Y.; Zhang, Y.; Sun, J.; Liu, Z.; Shen, Y.
    One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction (2013), Chem. Commun. (Camb.), 49, 10706-10708.
    View publication on PubMed

Application

Application Comment Organism
synthesis coupling of asymmetric oxidation of racemic 2-hydroxyacids with the opposite stereoselective reduction of 2-ketoacids for the stereoselective oxidoreductive deracemization to (R)-2-hydroxyacids, using a one-pot biocatalysis by resting cells of Saccharomyces cerevisiae strain ZJB5074 and Pseudomonas aeruginosa CCTCC M 2011394. Substituted racemic hydroxy(phenyl)acetic acids are converted to (R)-2-hydroxy-2-phenyl acetic acids with 55-98% conversion rate and 99.9% enantiomeric excess Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Pseudomonas aeruginosa CCTCC M2011394
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Cofactor

Cofactor Comment Organism Structure
FMN
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Pseudomonas aeruginosa