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Literature summary for 1.1.98.3 extracted from

  • Ribeiro, A.L.; Degiacomi, G.; Ewann, F.; Buroni, S.; Incandela, M.L.; Chiarelli, L.R.; Mori, G.; Kim, J.; Contreras-Dominguez, M.; Park, Y.S.; Han, S.J.; Brodin, P.; Valentini, G.; Rizzi, M.; Riccardi, G.; Pasca, M.R.
    Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis (2011), PLoS ONE, 6, e26675.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycolicibacterium smegmatis

Protein Variants

Protein Variants Comment Organism
additional information isolation of mutant strains resistant to dinitrobenzamides. All mutants show cross-resistance to benzothiazinones and dinitrobenzamides, and all the mutant strains with a higher level of resistance to dinitrobenzamides have a substitution C394G of MSMEG_6382 gene encoding decaprenylphospho-?-D-ribofuranose 2-oxidase Mycolicibacterium smegmatis

Inhibitors

Inhibitors Comment Organism Structure
additional information benzothiazinone and dinitrobenzamide inhibitors target decaprenylphospho-beta-D-ribofuranose 2-oxidase DprE1. Several mutants showing high levels of dinitrobenzamide resistance, exhibit a mutation in residue Cys394 of DprE1 Mycolicibacterium smegmatis

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R607
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Synonyms

Synonyms Comment Organism
DprE2
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Mycolicibacterium smegmatis
MSMEG_6382
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Mycolicibacterium smegmatis