Literature summary for 1.1.3.47 extracted from

Pickl, M.; Swoboda, A.; Romero, E.; Winkler, C.; Binda, C.; Mattevi, A.; Faber, K.; Fraaije, M.
Kinetic resolution of sec-thiols by enantioselective oxidation with rationally engineered 5-(hydroxymethyl)furfural oxidase (2018), Angew. Chem. Int. Ed. Engl., 57, 2864-2868 .

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Application

Application	Comment	Organism
synthesis	oxidative kinetic resolution of racemic sec-thiols by enzyme variants, yielding the corresponding thioketones and nonreacted R-configured thiols with excellent enantioselectivities (E+200)	Methylovorus sp. MP688

Protein Variants

Protein Variants	Comment	Organism
V465S	the active site is additionally enlarged by a Thr residue. This residue establishes a hydrogen-bonding interaction with the substrates and allows for enantioselective oxidation of a range of sec-thiols	Methylovorus sp. MP688
V465T	the active site is additionally enlarged by a Thr residue. This residue establishes a hydrogen-bonding interaction with the substrates and allows for enantioselective oxidation of a range of sec-thiols	Methylovorus sp. MP688

Organism

Organism	UniProt	Comment	Textmining
Methylovorus sp. MP688	E4QP00	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-(4-chlorophenyl)ethanethiol + O2	-	Methylovorus sp. MP688	1-(4-chlorophenyl)ethane-1-thione + (R)-1-(4-chlorophenyl)ethanethiol	-	?
1-(4-fluorophenyl)ethanethiol + O2	-	Methylovorus sp. MP688	1-(4-fluorophenyl)ethane-1-thione + (R)-1-(4-fluorophenyl)ethanethiol	-	?
1-(4-methylphenyl)ethanethiol + O2	-	Methylovorus sp. MP688	1-(4-methylphenyl)ethane-1-thione + (R)-1-(4-methylphenyl)ethanethiol	-	?
1-phenylethanethiol + O2	-	Methylovorus sp. MP688	1-phenylethane-1-thione + (R)-1-phenylethanethiol	-	?

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Release 2023.1 (January 2023)