Literature summary for 1.1.3.47 extracted from

Xu, J.; He, A.; Wu, B.; Hu, L.; Liu, X.; Wu, Z.; Xia, J.; Xu, J.; Zhou, S.
Redox-switchable biocatalyst for controllable oxidation or reduction of 5-hydroxymethylfurfural into high-value derivatives (2020), ACS Omega, 5, 19625-19632 .

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Application

Application	Comment	Organism
synthesis	utilization of whole-cell Paraburkholderia azotifigens F18 for selective reduction of 5-hydroxymethylfurfural to 2,5-bis(hydroxymethyl)furan (BHMF) or oxidation to 5-hydroxymethyl-2-furancarboxylic acid (HMFCA). The whole-cell system can proceed an efficient hydrogenation reaction toward 5-hydroxymethylfurfural with a good selectivity of 97.6% to yield the BHMF at 92.2%. BHMF can be further oxidized to HMFCA and 2,5-furandicarboxylic acid (FDCA). The genes encoding HMF oxidoreductase/oxidase of whole-cell F18 are then deleted to prevent the further conversion of HMFCA to FDCA, which leads to a 10-fold decrease of FDCA. An 5-hydroxymethylfurfural conversion of 100% with an HMFCA yield of 98.3% is finally achieved, with an selectivity of 96.3% and a yield of 85.1% even at a high substrate concentration of up to 200 mM	Paraburkholderia azotifigens

Organism

Organism	UniProt	Comment	Textmining
Paraburkholderia azotifigens	-	-	-
Paraburkholderia azotifigens F18	-	-	-

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Release 2023.1 (January 2023)