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Literature summary for 1.1.3.47 extracted from

  • Koopman, F.; Wierckx, N.; De Winde, J.; Ruijssenaars, H.
    Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14 (2010), Proc. Natl. Acad. Sci. USA, 107, 4919-4924.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.3.47

Cloned(Commentary)

Cloned (Comment) Organism
when the structural genes of the furfural catabolic pathway are expressed in a heterologous host, Pseudomonas putida S12, they yield a strain capable of utilizing 5-(hydroxymethyl)furfural and furfural as sole carbon sources Cupriavidus basilensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-(hydroxymethyl)furfural + 3 O2 + 2 H2O Cupriavidus basilensis overall reaction. the enzyme is involved in degradation of 5-(hydroxymethyl)furfural furan-2,5-dicarboxylate + 3 H2O2
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 ?

Organism

Organism UniProt Comment Textmining
Cupriavidus basilensis D5KB61
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-(hydroxymethyl)furfural + 3 O2 + 2 H2O overall reaction Cupriavidus basilensis furan-2,5-dicarboxylate + 3 H2O2
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 ?
5-(hydroxymethyl)furfural + 3 O2 + 2 H2O overall reaction. the enzyme is involved in degradation of 5-(hydroxymethyl)furfural Cupriavidus basilensis furan-2,5-dicarboxylate + 3 H2O2
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 ?

Synonyms

Synonyms Comment Organism
HMF/furfural oxidoreductase
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 Cupriavidus basilensis
HmfH
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 Cupriavidus basilensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
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 assay at Cupriavidus basilensis

General Information

General Information Comment Organism
malfunction mutants with a disrupted hmfH gene accumulate 5-hydroxymethylfuroic acid when cultured in the presence of 5-(hydroxymethyl)furfural Cupriavidus basilensis
metabolism the enzyme is involved in degradation of 5-(hydroxymethyl)furfural Cupriavidus basilensis