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Literature summary for 1.1.3.47 extracted from
- Enzyme-catalyzed oxidation of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid (2014), Angew. Chem. Int. Ed. Engl., 53, 6515-6518.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | biocatalytic production of furan-2,5-dicarboxylate, a biobased platform chemical for the production of polymers | Methylovorus sp. MP688 |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.085 | - |
terephthaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 |  |
| 0.15 | - |
4-(Hydroxymethyl)benzaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 1.4 | - |
5-(hydroxymethyl)furfural | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 1.7 | - |
furan-2,5-dicarbaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methylovorus sp. MP688 | E4QP00 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(hydroxymethyl)benzaldehyde + O2 + H2O | - |
Methylovorus sp. MP688 | ? | - |
? | |
| 5-(dihydroxymethyl)furan-2-carbaldehyde + O2 | - |
Methylovorus sp. MP688 | 5-formylfuran-2-carboxylate + H2O2 | spontaneous formation of 5-(dihydroxymethyl)furan-2-carboxylate from 5-formylfuran-2-carboxylate | ? | |
| 5-(dihydroxymethyl)furan-2-carboxylate + O2 | - |
Methylovorus sp. MP688 | furan-2,5-dicarboxylate + H2O2 | - |
? | |
| 5-(hydroxymethyl)furfural + 3 O2 + 2 H2O | overall reaction | Methylovorus sp. MP688 | furan-2,5-dicarboxylate + 3 H2O2 | - |
? | |
| 5-(hydroxymethyl)furfural + O2 | - |
Methylovorus sp. MP688 | furan-2,5-dicarbaldehyde + H2O2 | spontaneous formation of 5-(dihydroxymethyl)furan-2-carbaldehyde from furan-2,5-dicarbaldehyde | ? | |
| terephthaldehyde + O2 + H2O | - |
Methylovorus sp. MP688 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HFMO | - |
Methylovorus sp. MP688 |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Methylovorus sp. MP688 |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.3 | - |
terephthaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 1.6 | - |
furan-2,5-dicarbaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 8.6 | - |
4-(Hydroxymethyl)benzaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 9.9 | - |
5-(hydroxymethyl)furfural | pH 7.0, 25°C | Methylovorus sp. MP688 | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Methylovorus sp. MP688 |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.94 | - |
furan-2,5-dicarbaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 7 | - |
5-(hydroxymethyl)furfural | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 15 | - |
terephthaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
| 57 | - |
4-(Hydroxymethyl)benzaldehyde | pH 7.0, 25°C | Methylovorus sp. MP688 | |
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