Literature summary for 1.1.3.38 extracted from

Tahallah, N.; van den Heuvel, R.H.; van den Berg, W.A.; Maier, C.S.; van Berkel, W.J.; Heck, A.J.
Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase (2002), J. Biol. Chem., 277, 36425-36432.

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Protein Variants

Protein Variants	Comment	Organism
H61T	FAD-free apoenzyme H61T mainly exists as a dimeric species of 126000 Da. Binding of FAD to apoH61T rapidly restores enzyme activity and induces octamerization	Penicillium simplicissimum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
62742	-	8 * 62742, mutant enzyme H61T, apo-H61T: 15% octamer and 85% dimer, H61T + FAD: 78% octamer + 22% dimer, nanoelectrospray mass spectrometry	Penicillium simplicissimum
63561	-	8 * 63561, wild-type enzyme, 86% of the enzyme axists as octamer and 14% as dimer, nanoelectrospray mass spectrometry	Penicillium simplicissimum
504700	-	wild-type enzyme, nanoelectrospray mass spectrometry	Penicillium simplicissimum

Organism

Organism	UniProt	Comment	Textmining
Penicillium simplicissimum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
eugenol + O2 + H2O	-	Penicillium simplicissimum	coniferyl alcohol + H2O2	-	?

Subunits

Subunits	Comment	Organism
More	FAD-free apoenzyme H61T mainly exists as a dimeric species of 126000 Da. Binding of FAD to apoH61T rapidly restores enzyme activity and induces octamerization	Penicillium simplicissimum
octamer	8 * 62742, mutant enzyme H61T, apo-H61T: 15% octamer and 85% dimer, H61T + FAD: 78% octamer + 22% dimer, nanoelectrospray mass spectrometry	Penicillium simplicissimum
octamer	8 * 63561, wild-type enzyme, 86% of the enzyme axists as octamer and 14% as dimer, nanoelectrospray mass spectrometry	Penicillium simplicissimum

Synonyms

Synonyms	Comment	Organism
VAO	-	Penicillium simplicissimum

Cofactor

Cofactor	Comment	Organism	Structure
FAD	covalently bound	Penicillium simplicissimum

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Release 2023.1 (January 2023)