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Literature summary for 1.1.3.17 extracted from
- The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase (2004), Arch. Biochem. Biophys., 430, 264-273.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2-amino-ethyl)trimethylammonim chloride | - |
Arthrobacter globiformis |  |
| allyltrimethylammonium chloride | - |
Arthrobacter globiformis | |
| diethylmethylamine | - |
Arthrobacter globiformis | |
| Dimethylamine | - |
Arthrobacter globiformis | |
| dimethylethylamine | - |
Arthrobacter globiformis | |
| ethylamine | - |
Arthrobacter globiformis | |
| glycine betaine | - |
Arthrobacter globiformis | |
| methylamine | - |
Arthrobacter globiformis | |
| methylethylamine | - |
Arthrobacter globiformis | |
| N,N-dimethylglycine | - |
Arthrobacter globiformis | |
| N-methylglycine | - |
Arthrobacter globiformis | |
| tetramethylamine | - |
Arthrobacter globiformis | |
| trimethylamine | - |
Arthrobacter globiformis | |
| trimethylethylammonium chloride | - |
Arthrobacter globiformis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.32 | - |
N,N-dimethylethanolamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 0.43 | - |
choline | pH 8.0, 25°C | Arthrobacter globiformis | |
| 0.52 | - |
N-Methylethanolamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 1.01 | - |
3,3-dimethyl-1-butanol | pH 8.0, 25°C | Arthrobacter globiformis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arthrobacter globiformis | - |
strain ATCC 8010 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,3-dimethyl-butanol + O2 | - |
Arthrobacter globiformis | 3,3-dimethylbutanal + H2O2 | - |
? | |
| betaine aldehyde + O2 + H2O | - |
Arthrobacter globiformis | betaine + H2O2 | - |
? | |
| choline + O2 | - |
Arthrobacter globiformis | betaine aldehyde + H2O2 | - |
? | |
| N,N-dimethylethanolamine + O2 | - |
Arthrobacter globiformis | N,N-dimethylethanalamine + H2O2 | - |
? | |
| N-methylethanolamine + O2 | - |
Arthrobacter globiformis | N-methylethanalamine + H2O2 | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.37 | - |
N-Methylethanolamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 5.9 | - |
N,N-dimethylethanolamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 8 | - |
3,3-dimethyl-1-butanol | pH 8.0, 25°C | Arthrobacter globiformis | |
| 86 | - |
choline | pH 8.0, 25°C | Arthrobacter globiformis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.4 | - |
trimethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 5 | - |
diethylmethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 6 | - |
Dimethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 8 | - |
methylethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 9 | - |
dimethylethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 9 | - |
(2-amino-ethyl)trimethylammonim chloride | pH 8.0, 25°C | Arthrobacter globiformis | |
| 11 | - |
ethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 11 | - |
tetramethylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 13 | - |
trimethylethylammonium chloride | pH 8.0, 25°C | Arthrobacter globiformis | |
| 15 | - |
glycine betaine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 15 | - |
allyltrimethylammonium chloride | pH 8.0, 25°C | Arthrobacter globiformis | |
| 26 | - |
methylamine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 57 | - |
N,N-dimethylglycine | pH 8.0, 25°C | Arthrobacter globiformis | |
| 405 | - |
N-methylglycine | pH 8.0, 25°C | Arthrobacter globiformis | |
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