Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + beta-NAD+ | Rattus norvegicus | - |
11-dehydrocorticosterone + beta-NADH | - |
r | |
corticosterone + beta-NAD+ | Homo sapiens | - |
11-dehydrocorticosterone + beta-NADH | - |
r | |
corticosterone + beta-NAD+ | Rattus norvegicus Wistar | - |
11-dehydrocorticosterone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | Rattus norvegicus | - |
cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | Homo sapiens | - |
cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | Rattus norvegicus Wistar | - |
cortisone + beta-NADH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P80365 | - |
- |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Rattus norvegicus | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + beta-NADPH | low activity | Homo sapiens | corticosterone + beta-NADP+ | - |
r | |
11-dehydrocorticosterone + beta-NADPH | higher activity | Rattus norvegicus | corticosterone + beta-NADP+ | - |
r | |
11-dehydrocorticosterone + beta-NADPH | higher activity | Rattus norvegicus Wistar | corticosterone + beta-NADP+ | - |
r | |
corticosterone + beta-NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + beta-NADH | - |
r | |
corticosterone + beta-NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + beta-NADH | - |
r | |
corticosterone + beta-NAD+ | - |
Rattus norvegicus Wistar | 11-dehydrocorticosterone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | - |
Rattus norvegicus | cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | - |
Homo sapiens | cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | low activity | Rattus norvegicus | cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | higher activity | Homo sapiens | cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | - |
Rattus norvegicus Wistar | cortisone + beta-NADH | - |
r | |
cortisol + beta-NAD+ | low activity | Rattus norvegicus Wistar | cortisone + beta-NADH | - |
r | |
cortisone + beta-NADPH | low activity | Homo sapiens | cortisol + beta-NADP+ | - |
r | |
cortisone + beta-NADPH | higher activity | Rattus norvegicus | cortisol + beta-NADP+ | - |
r | |
cortisone + beta-NADPH | higher activity | Rattus norvegicus Wistar | cortisol + beta-NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Rattus norvegicus |
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
sterid reduction assay at | Homo sapiens |
6.5 | - |
steroid reduction assay at | Rattus norvegicus |
8 | - |
steroid oxidation assay at | Rattus norvegicus |
8 | - |
steroid oxidation assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus | |
NAD+ | - |
Homo sapiens | |
NADH | - |
Rattus norvegicus | |
NADH | - |
Homo sapiens | |
NADP+ | - |
Rattus norvegicus | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | species-specific differences of rat and human placental 11beta-HSD2 steroid turnover, species-specific expression of corticotropin-releasing hormone and steroids in human and rat term placenta | Rattus norvegicus |
additional information | species-specific differences of rat and human placental 11beta-HSD2 steroid turnover, species-specific expression of corticotropin-releasing hormone and steroids in human and rat term placenta | Homo sapiens |
physiological function | the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11b-HSD2) shields the fetus from maternal glucocorticoid excess by catalyzing the conversion of these hormones into biologically inactive derivatives | Homo sapiens |
physiological function | the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) shields the fetus from maternal glucocorticoid excess by catalyzing the conversion of these hormones into biologically inactive derivatives | Rattus norvegicus |