Literature summary for 1.1.1.B40 extracted from

Ergang, P.; Kuzelova, A.; Sotak, M.; Klusonova, P.; Makal, J.; Pacha, J.
Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus (2014), Physiol. Res., 63, 255-261 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene 11HSD1, genotyping, quantitative isozyme expression analysis in brain of different strains	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P16232	several strains	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	11HSD1 is highly expressed in various brain structures, including the hippocampus	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
11beta-hydroxysteroid dehydrogenase type 1	-	Rattus norvegicus
11HSD1	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	11HSD1 expression is increased by stress in the hippocampus, i.e. in the limbic structure that is activated by stress, effect of stress on the expression of 11HSD1 in the ventral and dorsal region of the CA1 hippocampus in three different rat strains with diverse responses to stress: Fisher 344, Lewis and Wistar. Stress stimulates 11HSD1 in the ventral but not dorsal CA1 hippocampus of Fisher 344 but not Lewis or Wistar rats	up

General Information

General Information	Comment	Organism
physiological function	11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) is an enzyme that regulates the conversion of glucocorticoids from inactive to active form. Expression of expression of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenase type 1 determines the sensitivity of the hippocampus to glucocorticoids, which mediate the feedbac inhibition of the hypothalamus-pituitary-adrenal axis during stress response via the hippocampus. Depending on the strain, stress stimulates 11HSD1 in the ventral hippocampus, which is known to be involved in stress and emotion reactions whereas independent of strain, stress inhibits the glucorticoid receptor in the dorsal hippocampus, which is predominantly involved in cognitive functions. F344 rats may amplify the hippocampal glucocorticoid signal more effectively than the stressed Wistar and Lewis rats, or the positive effect of stressful stimuli on 11HSD1 requires a longer stress exposure in the Wistar and Lewis Rattus strains	Rattus norvegicus

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Release 2023.1 (January 2023)