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Literature summary for 1.1.1.B40 extracted from

  • Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
    Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity (2009), J. Antibiot., 62, 239-242.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cell Mus musculus
expressed in HEK-293 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S)-5-(acetyloxy)-2-hydroxypentyl acetate
-
Homo sapiens
2-oxopentane-1,5-diyl diacetate
-
Homo sapiens
2-oxopentane-1,5-diyl diacetate
-
Mus musculus
5-hydroxy-4-oxopentyl acetate
-
Homo sapiens
5-hydroxy-4-oxopentyl acetate
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
Mus musculus cortisone + NADH + H+
-
?
cortisol + NAD+
-
Homo sapiens cortisone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase 2
-
Mus musculus
11beta-hydroxysteroid dehydrogenase 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NAD+
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
IC50 = 0.0051 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-oxopentane-1,5-diyl diacetate
additional information
-
IC50 = 0.0323 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 2-oxopentane-1,5-diyl diacetate
additional information
-
IC50 = 0.0389 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-hydroxy-4-oxopentyl acetate
additional information
-
IC50 = 0.1291 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 5-hydroxy-4-oxopentyl acetate
additional information
-
IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (2S)-5-(acetyloxy)-2-hydroxypentyl acetate