BRENDA - Enzyme Database show
show all sequences of 1.1.1.B40

Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity

Xu, D.; Sheng, Y.; Zhou, Z.Y.; Liu, R.; Leng, Y.; Liu, J.K.; Chem. Pharm. Bull. 57, 433-435 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in HEK-293 cell
Mus musculus
overexpressed in HEK-293 cell
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Homo sapiens
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
Mus musculus
glycyrrhizininc acid
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cortisol + NAD+
-
711737
Mus musculus
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
-
711737
Homo sapiens
cortisone + NADH + H+
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
NAD+
-
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
additional information
-
IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.2505 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.22 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.3303 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.2 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
additional information
-
IC50 = 0.5002 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
0.00000071
-
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
glycyrrhizininc acid
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in HEK-293 cell
Mus musculus
overexpressed in HEK-293 cell
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
NAD+
-
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
additional information
-
IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.2505 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.22 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.3303 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
IC50 = 0.2 mg/ml, pH not specified in the publication, temperature not specified in the publication
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
additional information
-
IC50 = 0.5002 mg/ml, pH not specified in the publication, temperature not specified in the publication
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
0.00000071
-
pH not specified in the publication, temperature not specified in the publication
Homo sapiens
glycyrrhizininc acid
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Homo sapiens
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
Mus musculus
glycyrrhizininc acid
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Mus musculus
-
-
microsome
-
Homo sapiens
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cortisol + NAD+
-
711737
Mus musculus
cortisone + NADH + H+
-
-
-
?
cortisol + NAD+
-
711737
Homo sapiens
cortisone + NADH + H+
-
-
-
?
Other publictions for EC 1.1.1.B40
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
726314
Hu
Curcumin as a potent and selec ...
Homo sapiens
PLoS ONE
8
e49976
2013
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
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-
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1
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-
-
-
-
725817
Kratschmar
Characterization of activity a ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
125
129-142
2011
-
-
1
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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2
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1
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2
4
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-
1
-
-
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-
-
-
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-
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-
725818
Zhao
The inhibition of human and ra ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
125
143-147
2011
-
-
-
-
-
-
2
-
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2
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2
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-
697286
Zhao
Structure-dependent inhibition ...
Homo sapiens, Rattus norvegicus
Chem. Biol. Interact.
183
79-84
2010
-
-
-
-
-
-
16
-
2
-
-
-
-
4
-
-
-
-
-
2
-
-
2
-
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-
-
-
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-
-
2
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-
5
-
-
-
2
-
-
-
5
16
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711471
Stanetty
Synthesis of novel 3-amino and ...
Homo sapiens
Bioorg. Med. Chem.
18
7522-7541
2010
-
-
1
-
-
-
27
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
27
-
-
1
1
-
-
-
27
27
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711694
Kim
Selection and optimization of ...
Homo sapiens
Cell Biochem. Funct.
28
440-447
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713232
Zhang
Rare merosesquiterpenoids from ...
Homo sapiens
Phytochemistry
71
100-103
2010
-
-
1
-
-
-
5
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
5
-
-
1
1
-
-
-
5
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696054
Hong
Mono-(2-ethylhexyl) phthalate ...
Mus musculus
Biochem. Biophys. Res. Commun.
389
305-309
2009
-
-
-
-
-
-
1
-
1
-
1
1
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
-
-
2
1
-
-
1
-
1
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697720
Mericq
Differences in expression and ...
Homo sapiens
Eur. J. Endocrinol.
161
419-425
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
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1
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1
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-
699841
Chen
The (+)- and (-)-gossypols pot ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
113
177-181
2009
-
-
-
-
-
-
8
-
-
-
-
2
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
8
-
-
-
2
-
-
-
8
8
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
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-
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-
-
-
699842
Classen-Houben
Selective inhibition of 11beta ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
113
248-252
2009
-
-
-
-
-
-
2
-
-
-
-
1
-
1
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-
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1
-
1
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1
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1
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1
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1
2
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1
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-
1
-
1
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-
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-
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-
-
-
-
-
-
699847
Sharp
Expression and activities of 1 ...
Sus scrofa
J. Steroid Biochem. Mol. Biol.
115
98-106
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
3
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-
10
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2
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1
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1
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1
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10
-
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2
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-
700178
Chapman
The role and regulation of 11b ...
Homo sapiens, Mus musculus
Mol. Cell. Endocrinol.
301
123-131
2009
2
1
-
-
-
-
2
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-
2
-
2
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15
-
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2
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2
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2
1
-
2
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2
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2
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15
-
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2
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-
711737
Xu
Sesquiterpenes from cultures o ...
Homo sapiens, Mus musculus
Chem. Pharm. Bull.
57
433-435
2009
-
-
2
-
-
-
7
-
2
-
-
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3
-
-
-
-
-
-
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-
2
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-
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-
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2
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7
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2
2
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-
7
7
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2
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2
-
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-
-
-
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-
712257
Zhang
Pentanol derivatives from basi ...
Homo sapiens, Mus musculus
J. Antibiot.
62
239-242
2009
-
-
2
-
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
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-
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2
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5
-
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2
2
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5
5
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2
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686234
Sadosky
Increased production of 11beta ...
Oryctolagus cuniculus, Saimiri, Sus scrofa
Comp. Med.
58
180-187
2008
-
1
-
-
-
-
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-
3
-
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3
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3
1
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1
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3
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3
1
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687317
Balazs
DHEA induces 11 -HSD2 by actin ...
Rattus norvegicus
J. Am. Soc. Nephrol.
19
92-101
2008
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1
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1
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1
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1
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1
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-
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-
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-
687328
Ito-Kobayashi
Sterenin A, B, C and D, novel ...
Homo sapiens
J. Antibiot.
61
128-135
2008
-
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1
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4
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1
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1
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4
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1
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4
4
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-
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-
-
1
-
-
-
-
-
-
-
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-
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-
-
-
688010
Sloboda
Expression of glucocorticoid r ...
Ovis aries
J. Endocrinol.
197
213-220
2008
-
1
-
-
-
-
-
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4
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1
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1
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1
-
-
-
-
-
-
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-
-
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-
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-
-
-
-
688766
Gong
Human renal 11beta-hydroxyster ...
Homo sapiens
Life Sci.
82
631-637
2008
-
-
-
-
-
-
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1
-
-
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-
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1
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1
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1
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1
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1
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1
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1
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-
1
-
-
-
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-
-
-
-
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-
-
-
693544
Johansson
2-amino-1,3-thiazol-4(5H)-ones ...
Homo sapiens
J. Med. Chem.
51
2933-2943
2008
-
-
1
-
-
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-
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1
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1
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1
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1
1
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-
1
-
-
-
-
-
-
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-
-
-
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-
-
-
-
693882
Honda
Leydig cells from neonatal pig ...
Sus scrofa
J. Steroid Biochem. Mol. Biol.
108
91-101
2008
-
-
-
-
-
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2
1
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1
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2
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1
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2
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2
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2
1
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694281
Sakumoto
Changes in expression of 11bet ...
Sus scrofa
Mol. Reprod. Dev.
75
925-930
2008
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695148
Klusonova
Chicken 11beta-hydroxysteroid ...
Gallus gallus
Steroids
73
348-355
2008
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
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8
-
-
-
1
-
-
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-
-
-
-
-
-
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-
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-
1
-
-
-
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1
-
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-
-
8
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695443
Henschkowski
Age-dependent decrease in 11be ...
Homo sapiens
Am. J. Hypertens.
21
644-649
2008
-
1
-
-
-
-
-
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1
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-
-
-
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-
-
-
-
-
-
-
-
701239
Gong
Variable expression of 11beta ...
Bos taurus, Homo sapiens, Rattus norvegicus
Steroids
73
1187-1196
2008
-
-
-
-
-
-
-
-
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3
-
-
3
-
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11
-
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3
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11
-
-
-
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-
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-
-
-
-
687961
Jang
Altered activity of 11beta-hyd ...
Homo sapiens
J. Clin. Endocrinol. Metab.
92
3314-3320
2007
1
1
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-
-
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1
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1
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1
1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689337
Garbrecht
11-beta Hydroxysteroid dehydro ...
Homo sapiens
Pediatr. Res.
62
26-31
2007
-
-
-
-
-
-
2
-
-
-
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1
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1
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1
-
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-
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-
-
-
-
-
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-
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-
-
-
-
-
-
693380
Chandras
PTGER1 and PTGER2 receptors me ...
Homo sapiens
J. Endocrinol.
194
595-602
2007
1
-
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-
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-
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693880
Milagro
11-Beta hydroxysteroid dehydro ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
104
81-84
2007
-
1
-
-
-
-
-
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4
-
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695090
Sharp
11Beta-hydroxysteroid dehydrog ...
Sus scrofa
Reproduction
134
473-482
2007
-
-
-
-
-
-
-
3
-
-
1
1
-
1
-
-
-
-
-
9
-
-
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
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3
-
-
1
1
-
-
-
-
-
9
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667151
Kossintseva
Proinflammatory cytokines inhi ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
290
E282-E288
2006
-
-
-
-
-
-
6
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
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-
1
-
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-
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-
-
1
-
-
-
-
6
-
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2
-
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-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667152
Garbrecht
11beta-Hydroxysteroid dehydrog ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
290
E653-E660
2006
-
-
-
-
-
-
1
-
1
-
1
2
-
1
-
-
-
-
-
3
-
-
3
1
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
1
2
-
-
-
-
-
3
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668297
Jang
11beta Hydroxysteroid dehydrog ...
Homo sapiens
Clin. Endocrinol. (Oxf.)
65
800-805
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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-
-
1
-
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1
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-
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-
1
-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668379
Basu
Splanchnic cortisol production ...
Canis lupus familiaris
Diabetes
55
3013-3019
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668425
Groyer
Expression and functional stat ...
Rattus norvegicus
Endocrinology
147
4339-4350
2006
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
668426
Ozaki
Roles of 11beta-hydroxysteroid ...
Anguilla japonica
Endocrinology
147
5139-5146
2006
2
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670896
Temkin
-
Type 2 11beta-hydroxysteroid d ...
Homo sapiens
Steroids
7
1019-1023
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667203
Denari
Seasonal changes in the activi ...
Rhinella arenarum
Ann. N. Y. Acad. Sci.
1040
297-300
2005
-
-
-
-
-
-
1
3
3
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
3
3
-
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667673
Zhang
Crystal structure of murine 11 ...
Mus musculus
Biochemistry
44
6948-6957
2005
-
1
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667956
Xiang
Synthesis and biological evalu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
2865-2869
2005
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667962
Olson
Adamantyl triazoles as selecti ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
15
4359-4362
2005
-
-
-
-
-
-
24
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
24
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668432
Ohshima
Inhibitory effects of some pos ...
Homo sapiens
Environ. Sci.
12
219-230
2005
-
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668505
Claus
Characterization of 11beta-hyd ...
Sus scrofa
Exp. Clin. Endocrinol. Diabetes
113
262-267
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
669706
Carvajal
Biochemical and genetic charac ...
Homo sapiens
J. Hypertens.
23
71-77
2005
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669907
Arampatzis
Comparative enzymology of 11be ...
Canis lupus familiaris, Cavia porcellus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
J. Mol. Endocrinol.
35
89-101
2005
-
1
6
-
-
-
48
12
-
-
6
13
-
7
-
-
-
6
-
1
6
-
27
12
6
-
-
-
6
-
-
13
56
-
-
-
2
6
13
-
-
-
-
55
56
12
-
-
6
13
-
-
-
-
-
1
7
-
27
12
7
-
-
-
7
-
-
-
-
-
-
-
-
-
670034
Mazancova
11beta-Hydroxysteroid dehydrog ...
Rattus norvegicus
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Expression of 11beta-hydroxyst ...
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Regulation of 11beta-hydroxyst ...
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654196
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11beta-Hydroxysteroid dehydrog ...
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Localization of 11beta-hydroxy ...
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Myometrial expression of 11bet ...
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Cloning and tissue distributio ...
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Characterization of 11beta-hyd ...
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The forms and functions of 11b ...
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Expression and characterizatio ...
Oryctolagus cuniculus
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Hundertmark
11-beta-Hydroxysteroid dehydro ...
Rattus norvegicus
Enzyme Protein
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