Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3alpha,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid | - |
Homo sapiens | |
(3alpha,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oicacid | - |
Homo sapiens | |
(3alpha,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3alpha,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta)-3-(acetyloxy)-11-oxoolean-12-en-30-oic acid | - |
Homo sapiens | |
(3beta)-3-hydroxy-11-oxoolean-12-en-30-amide | - |
Homo sapiens | |
(3beta)-N,3-dihydroxy-11-oxoolean-12-en-30-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-11-oxo-3-succinylamino-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-3,N-dihydroxy-N-methyl-11-oxo-olean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-(2-carboxy-ethylsulfonylamino)-11-oxoolean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-(2-methoxycarbonyl-ethylsulfonylamino)-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-acetoxy-N-methoxy-11-oxo-olean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-acetylamino-N-hydroxy-N-methyl-11-oxoolean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-amino-11-oxoolean-12-en-29-oic acid, diphenylmethyl ester | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid | - |
Homo sapiens | |
(3beta,18beta,20beta)-N-hydroxy-N-methyl-11-oxo-3-[(trifluoromethylsulfonyl)amino]-olean-12-en-29-amide | - |
Homo sapiens | |
(3beta,18beta,20beta)-N-hydroxy-N-methyl-3-methoxyamino-11-oxo-olean-12-en-29-amide | - |
Homo sapiens | |
(3E)-3-(methoxyimino)-11-oxoolean-12-en-30-oic acid | - |
Homo sapiens | |
3,11-dioxoolean-12-en-30-oic acid | - |
Homo sapiens | |
carbenoxolone | - |
Homo sapiens | |
glycyrrhetinic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
13% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta)-3-hydroxy-11-oxoolean-12-en-30-amide | |
additional information | - |
13% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-11-oxo-3-succinylamino-olean-12-en-29-oic acid | |
additional information | - |
2% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | carbenoxolone | |
additional information | - |
22% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid | |
additional information | - |
3% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-(2-methoxycarbonyl-ethylsulfonylamino)-11-oxo-olean-12-en-29-oic acid | |
additional information | - |
30% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-N-hydroxy-N-methyl-3-methoxyamino-11-oxo-olean-12-en-29-amide | |
additional information | - |
36% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-acetoxy-N-methoxy-11-oxo-olean-12-en-29-amide | |
additional information | - |
4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3alpha,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid | |
additional information | - |
4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-methylsulfonylamino-11-oxo-olean-12-en-29-oic acid | |
additional information | - |
4% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-acetylamino-N-hydroxy-N-methyl-11-oxoolean-12-en-29-amide | |
additional information | - |
4% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3alpha,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oicacid | |
additional information | - |
40% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-(2-carboxy-ethylsulfonylamino)-11-oxoolean-12-en-29-oic acid | |
additional information | - |
42% residual activity at 0,001 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-amino-11-oxoolean-12-en-29-oic acid, diphenylmethyl ester | |
additional information | - |
44% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-N-hydroxy-N-methyl-11-oxo-3-[(trifluoromethylsulfonyl)amino]-olean-12-en-29-amide | |
additional information | - |
50% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3alpha,18beta,20beta)-11-oxo-3-trifluoromethylsulfonylaminoolean-12-en-29-oic acid | |
additional information | - |
7% residual activity at 0,0002 mM, pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3,N-dihydroxy-N-methyl-11-oxo-olean-12-en-29-amide | |
0.0000029 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide | |
0.0000049 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3alpha,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid | |
0.0000145 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid | |
0.0000611 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide | |
0.000122 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta)-N,3-dihydroxy-11-oxoolean-12-en-30-amide | |
0.000257 | - |
pH not specified in the publication, 37°C | Homo sapiens | glycyrrhetinic acid | |
0.000268 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3E)-3-(methoxyimino)-11-oxoolean-12-en-30-oic acid | |
0.000329 | - |
pH not specified in the publication, 37°C | Homo sapiens | 3,11-dioxoolean-12-en-30-oic acid | |
0.000458 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-(acetylamino)-11-oxo-olean-12-en-29-oic acid | |
0.00075 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta)-3-(acetyloxy)-11-oxoolean-12-en-30-oic acid | |
0.00213 | - |
pH not specified in the publication, 37°C | Homo sapiens | (3beta,18beta,20beta)-3-hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide |