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Literature summary for 1.1.1.B40 extracted from

  • Chapman, K.E.; Coutinho, A.E.; Gray, M.; Gilmour, J.S.; Savill, J.S.; Seckl, J.R.
    The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response (2009), Mol. Cell. Endocrinol., 301, 123-131.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Mus musculus
additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Homo sapiens

Application

Application Comment Organism
medicine 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Homo sapiens
interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corticosterone + NAD+ Mus musculus
-
11-dehydrocorticosterone + NADH + H+
-
ir
corticosterone + NAD+ Homo sapiens
-
11-dehydrocorticosterone + NADH + H+
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Mus musculus
-
adipose tissue
-
Homo sapiens
-
aortic smooth muscle cell
-
Mus musculus
-
aortic smooth muscle cell
-
Homo sapiens
-
colon
-
Mus musculus
-
colon
-
Homo sapiens
-
granulosa cell
-
Mus musculus
-
granulosa cell
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
lung
-
Mus musculus
-
lung
-
Homo sapiens
-
lymph node peripheral lymph nodes and mesenteric lymph nodes Mus musculus
-
MG-63 cell
-
Mus musculus
-
MG-63 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + NAD+
-
Mus musculus 11-dehydrocorticosterone + NADH + H+
-
ir
corticosterone + NAD+
-
Homo sapiens 11-dehydrocorticosterone + NADH + H+
-
ir

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
Mus musculus
11beta-HSD2
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
Mus musculus
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NAD+
-
Homo sapiens