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Literature summary for 1.1.1.B40 extracted from
- Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells (2009), Biochem. Biophys. Res. Commun., 389, 305-309.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| mono-(2-ethylhexyl) phthalate | mono-(2-ethylhexyl) phthalate inhibits mRNA level and enzyme activity of 11beta-HSD2 in LbetaT2 cells at 0.0001 mM | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | 11beta-HSD2 | Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
11beta-HSD2, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | Mus musculus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| LbetaT2 cell | 11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells | Mus musculus | - |
| liver | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | - |
Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
| corticosterone + NAD+ | 11beta-HSD2 | Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Mus musculus |
| 11beta-HSD2 (oxidase) NAD+ | - |
Mus musculus |
| 11beta-hydroxysteroid dehydrogenase 2 | - |
Mus musculus |
| More | cf. EC 1.1.1.146, 11beta-HSD1 | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | preferred cofactor of 11beta-HSD2 | Mus musculus | |
| NAD+ | preferred cofactor of 11beta-HSD2, compared to 11beta-HSD1 | Mus musculus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0168 | - |
11beta-HSD2 from LbetaT2 cell microsomes, in PBS (pH 7.4), at 37°C | Mus musculus | mono-(2-ethylhexyl) phthalate | |
| 0.3279 | - |
11beta-HSD2 from kidney microsomes, in PBS (pH 7.4), at 37°C | Mus musculus | mono-(2-ethylhexyl) phthalate | |
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Release 2023.1 (January 2023)
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