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Literature summary for 1.1.1.B40 extracted from

  • Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Rohner-Jeanrenaud, F.; Odermatt, A.
    DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins (2008), J. Am. Soc. Nephrol., 19, 92-101.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine treatment of rats with dehydroepiandrosterone induces a shift from isoform 11beta-HSD1 to 11beta-HSD2 expression, increasing conversion from active to inactive glucocorticoids Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(3beta)-3-hydroxyandrost-5-en-17-one treatment of rats induces a shift from isoform 11beta-HSD1 to 11beta-HSD2 expression, increasing conversion from active to inactive glucocorticoids. Dehydroepiandrosterone likely modulates the transcription of 11beta-HSD2 in a phosphatidylinositol-3 kinase/Akt-dependent manner by increasing CCAAT/enhancer-binding protein beta mRNA and protein expression Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
RCCD-2 cell renal cortical collecting duct cell line Rattus norvegicus
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