Literature summary for 1.1.1.B40 extracted from

Temkin, S.; Nacharaju, V.L.; Hellman, M.; Lee, Y.C.; Abulafia, O.
Type 2 11beta-hydroxysteroid dehydrogenase activity in human ovarian cancer (2006), Steroids, 7, 1019-1023.

No PubMed abstract available

Search for more literature for 1.1.1.B40

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cortisol + NAD+	Homo sapiens	isozyme 11beta-HSD2 catalyzes the oxidative reaction with cofactor NAD+	cortisone + NADH	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	seven different women with ovarian cancer of different types, overview	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovarian cancer cell	expression and activity of isozyme 11beta-HSD2 in probes of seven different women with ovarian cancer of different types, overview	Homo sapiens	-
ovary	surface epithelium	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	determination of activity of isozyme 11beta-HSD2 in ovarian cancer, overview	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cortisol + NAD+	isozyme 11beta-HSD2 catalyzes the oxidative reaction with cofactor NAD+	Homo sapiens	cortisone + NADH	-	ir

Synonyms

Synonyms	Comment	Organism
11beta-HSD2	-	Homo sapiens
type 2 11beta-hydroxysteroid dehydrogenase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)