Literature summary for 1.1.1.B40 extracted from

Arampatzis, S.; Kadereit, B.; Schuster, D.; Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Langer, T.; Odermatt, A.
Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species (2005), J. Mol. Endocrinol., 35, 89-101.

Search for more literature for 1.1.1.B40

Application

Application	Comment	Organism
drug development	the enzyme is a target for inhibitor design and development	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells	Rattus norvegicus
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells	Mesocricetus auratus
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells	Homo sapiens
expression of isozyme 11beta-HSD1 in HEK-293 cells	Cavia porcellus
isozyme 11beta-HSD1, expression in HEK-293 cells	Mus musculus
isozyme 11beta-HSD1, expression in HEK-293 cells	Canis lupus familiaris

Inhibitors

Inhibitors	Comment	Organism
2'-hydroxyflavanone	-	Canis lupus familiaris
2'-hydroxyflavanone	-	Cavia porcellus
2'-hydroxyflavanone	-	Homo sapiens
2'-hydroxyflavanone	-	Mesocricetus auratus
2'-hydroxyflavanone	-	Mus musculus
2'-hydroxyflavanone	-	Rattus norvegicus
abietic acid	-	Canis lupus familiaris
abietic acid	-	Cavia porcellus
abietic acid	-	Homo sapiens
abietic acid	-	Mesocricetus auratus
abietic acid	-	Mus musculus
abietic acid	-	Rattus norvegicus
carbenoxolone	-	Canis lupus familiaris
carbenoxolone	-	Cavia porcellus
carbenoxolone	-	Homo sapiens
carbenoxolone	-	Mesocricetus auratus
carbenoxolone	-	Mus musculus
carbenoxolone	-	Rattus norvegicus
chenodeoxycholic acid	-	Canis lupus familiaris
chenodeoxycholic acid	-	Cavia porcellus
chenodeoxycholic acid	-	Homo sapiens
chenodeoxycholic acid	-	Mesocricetus auratus
chenodeoxycholic acid	-	Mus musculus
chenodeoxycholic acid	-	Rattus norvegicus
flavanone	-	Canis lupus familiaris
flavanone	-	Cavia porcellus
flavanone	-	Homo sapiens
flavanone	-	Mesocricetus auratus
flavanone	-	Mus musculus
flavanone	-	Rattus norvegicus
glycyrrhetinic acid	-	Canis lupus familiaris
glycyrrhetinic acid	-	Cavia porcellus
glycyrrhetinic acid	-	Homo sapiens
glycyrrhetinic acid	-	Mesocricetus auratus
glycyrrhetinic acid	-	Mus musculus
glycyrrhetinic acid	-	Rattus norvegicus
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Canis lupus familiaris
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Cavia porcellus
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Homo sapiens
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Mesocricetus auratus
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Mus musculus
additional information	inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL	Rattus norvegicus
T0504	-	Canis lupus familiaris
T0504	-	Cavia porcellus
T0504	-	Homo sapiens
T0504	-	Mesocricetus auratus
T0504	-	Mus musculus
T0504	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism
0.00038	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Mus musculus
0.00042	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Homo sapiens
0.00043	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Cavia porcellus
0.00045	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Mesocricetus auratus
0.00052	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Mus musculus
0.00052	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Homo sapiens
0.00057	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Mesocricetus auratus
0.00057	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Canis lupus familiaris
0.00064	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Cavia porcellus
0.00085	-	11-Dehydrocorticosterone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Rattus norvegicus
0.00136	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Rattus norvegicus
0.00157	-	cortisone	pH 7.4, 37°C, recombinant isozyme 11beta-HSD1	Canis lupus familiaris

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32000	-	x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Cavia porcellus
33000	-	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Mus musculus
33000	-	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Rattus norvegicus
33000	-	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Mesocricetus auratus
35000	-	x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Canis lupus familiaris
35000	-	x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
11-dehydrocorticosterone + NADPH	Mus musculus	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	Rattus norvegicus	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	Canis lupus familiaris	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	Mesocricetus auratus	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	Homo sapiens	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	Cavia porcellus	isozyme 11beta-HSD1	corticosterone + NADP+	-	?
cortisol + NAD+	Homo sapiens	isozyme 11beta-HSD2	cortisone + NADH	-	ir
cortisone + NADPH + H+	Mus musculus	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?
cortisone + NADPH + H+	Rattus norvegicus	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?
cortisone + NADPH + H+	Canis lupus familiaris	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?
cortisone + NADPH + H+	Mesocricetus auratus	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?
cortisone + NADPH + H+	Homo sapiens	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?
cortisone + NADPH + H+	Cavia porcellus	isozyme 11beta-HSD1, activation	cortisol + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	poodle, isozyme 11beta-HSD1	-
Cavia porcellus	Q6QLL4	isozyme 11beta-HSD1; gene HSD11B1, isozyme 11beta-HSD1	-
Homo sapiens	P28845	isozyme 11beta-HSD2; isozyme 11beta-HSD2	-
Homo sapiens	P80365	isozyme 11beta-HSD1; isozyme 11beta-HSD1	-
Mesocricetus auratus	Q6R0J2	isozyme 11beta-HSD1; isozyme 11beta-HSD1	-
Mus musculus	-	isozyme 11beta-HSD1	-
Rattus norvegicus	-	isozyme 11beta-HSD1	-

Reaction

Reaction	Comment	Organism	Reaction ID
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Mus musculus	a
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Rattus norvegicus	a
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Canis lupus familiaris	a
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Mesocricetus auratus	a
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Homo sapiens	a
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+	the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview	Cavia porcellus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Canis lupus familiaris	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Mus musculus
additional information	-	-	Rattus norvegicus
additional information	-	-	Canis lupus familiaris
additional information	-	-	Mesocricetus auratus
additional information	-	-	Homo sapiens
additional information	-	-	Cavia porcellus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Mus musculus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Rattus norvegicus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Canis lupus familiaris	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Mesocricetus auratus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Homo sapiens	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1	Cavia porcellus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	isozyme 11beta-HSD1, low activity	Canis lupus familiaris	corticosterone + NADP+	-	?
2 7-oxocholesterol + 2 NADPH + 2 H+	isozyme 11beta-HSD1, stereospecific reaction	Mesocricetus auratus	7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+	-	?
7-oxocholesterol + NADPH + H+	isozyme 11beta-HSD1, stereospecific reaction	Mus musculus	7beta-hydroxycholesterol + NADP+	-	?
7-oxocholesterol + NADPH + H+	isozyme 11beta-HSD1, stereospecific reaction	Rattus norvegicus	7beta-hydroxycholesterol + NADP+	-	?
7-oxocholesterol + NADPH + H+	isozyme 11beta-HSD1, stereospecific reaction	Homo sapiens	7beta-hydroxycholesterol + NADP+	-	?
7-oxocholesterol + NADPH + H+	isozyme 11beta-HSD1, stereospecific reaction, very low activity	Canis lupus familiaris	7beta-hydroxycholesterol + NADP+	-	?
7-oxocholesterol + NADPH + H+	isozyme 11beta-HSD1, stereospecific reaction, very low activity	Cavia porcellus	7beta-hydroxycholesterol + NADP+	-	?
cortisol + NAD+	isozyme 11beta-HSD2	Homo sapiens	cortisone + NADH	-	ir
cortisol + NAD+	isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+	Homo sapiens	cortisone + NADH	-	ir
cortisone + NADPH + H+	isozyme 11beta-HSD1	Mus musculus	cortisol + NADP+	-	r
cortisone + NADPH + H+	isozyme 11beta-HSD1	Rattus norvegicus	cortisol + NADP+	-	r
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Mus musculus	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Rattus norvegicus	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Canis lupus familiaris	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Mesocricetus auratus	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Homo sapiens	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, activation	Cavia porcellus	cortisol + NADP+	-	?
cortisone + NADPH + H+	isozyme 11beta-HSD1, high activity	Mesocricetus auratus	cortisol + NADP+	-	r
cortisone + NADPH + H+	isozyme 11beta-HSD1, high activity	Cavia porcellus	cortisol + NADP+	-	r
cortisone + NADPH + H+	isozyme 11beta-HSD1, low activity	Canis lupus familiaris	cortisol + NADP+	-	r
cortisone + NADPH + H+	isozyme 11beta-HSD1, preferred substrate, high activity	Homo sapiens	cortisol + NADP+	-	r

Subunits

Subunits	Comment	Organism
?	x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Cavia porcellus
?	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Mus musculus
?	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Rattus norvegicus
?	x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Mesocricetus auratus
?	x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Canis lupus familiaris
?	x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE	Homo sapiens
More	structure molecular modeling	Mus musculus
More	structure molecular modeling	Rattus norvegicus
More	structure molecular modeling	Canis lupus familiaris
More	structure molecular modeling	Mesocricetus auratus
More	structure molecular modeling	Homo sapiens
More	structure molecular modeling	Cavia porcellus

Synonyms

Synonyms	Comment	Organism
11beta-HSD1	-	Mus musculus
11beta-HSD1	-	Rattus norvegicus
11beta-HSD1	-	Canis lupus familiaris
11beta-HSD1	-	Mesocricetus auratus
11beta-HSD1	-	Homo sapiens
11beta-HSD1	-	Cavia porcellus
11beta-HSD2	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1	-	Mus musculus
11beta-hydroxysteroid dehydrogenase type 1	-	Rattus norvegicus
11beta-hydroxysteroid dehydrogenase type 1	-	Canis lupus familiaris
11beta-hydroxysteroid dehydrogenase type 1	-	Mesocricetus auratus
11beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1	-	Cavia porcellus
11beta-hydroxysteroid dehydrogenase type 2	-	Homo sapiens
7-alpha-HCD	-	Mesocricetus auratus
7-alpha-hydroxycholesterol dehydrogenase	-	Mesocricetus auratus
corticosteroid 11-beta-dehydrogenase isozyme 1	-	Mesocricetus auratus
corticosteroid 11-beta-dehydrogenase isozyme 1	-	Cavia porcellus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus
37	-	assay at	Rattus norvegicus
37	-	assay at	Canis lupus familiaris
37	-	assay at	Mesocricetus auratus
37	-	assay at	Homo sapiens
37	-	assay at	Cavia porcellus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mus musculus
7.4	-	assay at	Rattus norvegicus
7.4	-	assay at	Canis lupus familiaris
7.4	-	assay at	Mesocricetus auratus
7.4	-	assay at	Homo sapiens
7.4	-	assay at	Cavia porcellus

Cofactor

Cofactor	Comment	Organism
NAD+	-	Homo sapiens
NADP+	-	Mus musculus
NADP+	-	Rattus norvegicus
NADP+	-	Canis lupus familiaris
NADP+	-	Mesocricetus auratus
NADP+	-	Homo sapiens
NADP+	-	Cavia porcellus
NADPH	-	Mus musculus
NADPH	-	Rattus norvegicus
NADPH	-	Canis lupus familiaris
NADPH	-	Mesocricetus auratus
NADPH	-	Homo sapiens
NADPH	-	Cavia porcellus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000006	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.000015	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.000025	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.000025	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.000028	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.00008	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.000082	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.00011	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.00012	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.00012	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.00023	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.00023	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.00025	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.00028	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.00029	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.0003	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.00033	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.00034	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.00035	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.00043	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.00044	-	glycyrrhetinic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.00055	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.00059	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.00077	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.00094	-	carbenoxolone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.0012	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.0018	-	T0504	pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.002	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.0021	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.0021	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.0021	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.0025	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.003	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.0039	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.0049	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.0049	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.0052	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.0061	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.0064	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.007	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.007	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.0097	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.011	-	abietic acid	pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.015	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.017	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction	Homo sapiens
0.019	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.02	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.031	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction	Homo sapiens
0.031	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Cavia porcellus
0.034	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mus musculus
0.035	-	chenodeoxycholic acid	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Mesocricetus auratus
0.035	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Canis lupus familiaris
0.05	-	2'-hydroxyflavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.054	-	flavanone	pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation	Rattus norvegicus
0.2	-	flavanone	above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens
0.2	-	2'-hydroxyflavanone	above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation	Homo sapiens