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show all sequences of 1.1.1.B40

Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species

Arampatzis, S.; Kadereit, B.; Schuster, D.; Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Langer, T.; Odermatt, A.; J. Mol. Endocrinol. 35, 89-101 (2005)

Data extracted from this reference:

Application
Application
Commentary
Organism
drug development
the enzyme is a target for inhibitor design and development; the enzyme is a target for inhibitor design and development
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Homo sapiens
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Mesocricetus auratus
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Rattus norvegicus
expression of isozyme 11beta-HSD1 in HEK-293 cells
Cavia porcellus
isozyme 11beta-HSD1, expression in HEK-293 cells
Canis lupus familiaris
isozyme 11beta-HSD1, expression in HEK-293 cells
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
2'-hydroxyflavanone
-
Canis lupus familiaris
2'-hydroxyflavanone
-
Cavia porcellus
2'-hydroxyflavanone
;
Homo sapiens
2'-hydroxyflavanone
-
Mesocricetus auratus
2'-hydroxyflavanone
-
Mus musculus
2'-hydroxyflavanone
-
Rattus norvegicus
abietic acid
-
Canis lupus familiaris
abietic acid
-
Cavia porcellus
abietic acid
;
Homo sapiens
abietic acid
-
Mesocricetus auratus
abietic acid
-
Mus musculus
abietic acid
-
Rattus norvegicus
carbenoxolone
-
Canis lupus familiaris
carbenoxolone
-
Cavia porcellus
carbenoxolone
;
Homo sapiens
carbenoxolone
-
Mesocricetus auratus
carbenoxolone
-
Mus musculus
carbenoxolone
-
Rattus norvegicus
chenodeoxycholic acid
-
Canis lupus familiaris
chenodeoxycholic acid
-
Cavia porcellus
chenodeoxycholic acid
;
Homo sapiens
chenodeoxycholic acid
-
Mesocricetus auratus
chenodeoxycholic acid
-
Mus musculus
chenodeoxycholic acid
-
Rattus norvegicus
flavanone
-
Canis lupus familiaris
flavanone
-
Cavia porcellus
flavanone
;
Homo sapiens
flavanone
-
Mesocricetus auratus
flavanone
-
Mus musculus
flavanone
-
Rattus norvegicus
glycyrrhetinic acid
-
Canis lupus familiaris
glycyrrhetinic acid
-
Cavia porcellus
glycyrrhetinic acid
;
Homo sapiens
glycyrrhetinic acid
-
Mesocricetus auratus
glycyrrhetinic acid
-
Mus musculus
glycyrrhetinic acid
-
Rattus norvegicus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Canis lupus familiaris
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Cavia porcellus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Homo sapiens
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Mesocricetus auratus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Mus musculus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Rattus norvegicus
T0504
-
Canis lupus familiaris
T0504
-
Cavia porcellus
T0504
;
Homo sapiens
T0504
-
Mesocricetus auratus
T0504
-
Mus musculus
T0504
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00038
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mus musculus
0.00042
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Homo sapiens
0.00043
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Cavia porcellus
0.00045
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mesocricetus auratus
0.00052
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Homo sapiens
0.00052
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mus musculus
0.00057
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Canis lupus familiaris
0.00057
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mesocricetus auratus
0.00064
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Cavia porcellus
0.00085
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Rattus norvegicus
0.00136
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Rattus norvegicus
0.00157
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Canis lupus familiaris
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
32000
-
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Cavia porcellus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mesocricetus auratus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mus musculus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Rattus norvegicus
35000
-
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Canis lupus familiaris
35000
-
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
11-dehydrocorticosterone + NADPH
Mus musculus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Rattus norvegicus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Canis lupus familiaris
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Mesocricetus auratus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Homo sapiens
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Cavia porcellus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
cortisol + NAD+
Homo sapiens
isozyme 11beta-HSD2
cortisone + NADH
-
-
ir
cortisone + NADPH
Mus musculus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Rattus norvegicus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Canis lupus familiaris
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Mesocricetus auratus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Homo sapiens
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Cavia porcellus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Canis lupus familiaris
-
poodle, isozyme 11beta-HSD1
-
Cavia porcellus
Q6QLL4
isozyme 11beta-HSD1; gene HSD11B1, isozyme 11beta-HSD1
-
Homo sapiens
P28845
isozyme 11beta-HSD2; isozyme 11beta-HSD2
-
Homo sapiens
P80365
isozyme 11beta-HSD1; isozyme 11beta-HSD1
-
Mesocricetus auratus
Q6R0J2
isozyme 11beta-HSD1; isozyme 11beta-HSD1
-
Mus musculus
-
isozyme 11beta-HSD1
-
Rattus norvegicus
-
isozyme 11beta-HSD1
-
Reaction
Reaction
Commentary
Organism
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Canis lupus familiaris
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Cavia porcellus
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview; the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Homo sapiens
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Mesocricetus auratus
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Mus musculus
an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+
the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Canis lupus familiaris
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Canis lupus familiaris
additional information
-
-
Cavia porcellus
additional information
-
;
Homo sapiens
additional information
-
-
Mesocricetus auratus
additional information
-
-
Mus musculus
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Mus musculus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Rattus norvegicus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Canis lupus familiaris
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Mesocricetus auratus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Homo sapiens
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Cavia porcellus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1, low activity
669907
Canis lupus familiaris
corticosterone + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Mus musculus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Rattus norvegicus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Homo sapiens
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction, very low activity
669907
Canis lupus familiaris
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction, very low activity
669907
Cavia porcellus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Mesocricetus auratus
7alpha-hydroxycholesterol + NADP+
-
-
-
?
cortisol + NAD+
isozyme 11beta-HSD2
669907
Homo sapiens
cortisone + NADH
-
-
-
ir
cortisol + NAD+
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
669907
Homo sapiens
cortisone + NADH
-
-
-
ir
cortisone + NADPH
isozyme 11beta-HSD1
669907
Mus musculus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1
669907
Rattus norvegicus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Mus musculus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Rattus norvegicus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Canis lupus familiaris
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Mesocricetus auratus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Homo sapiens
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Cavia porcellus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, high activity
669907
Mesocricetus auratus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, high activity
669907
Cavia porcellus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, low activity
669907
Canis lupus familiaris
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, preferred substrate, high activity
669907
Homo sapiens
cortisol + NADP+
-
-
-
r
Subunits
Subunits
Commentary
Organism
?
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Canis lupus familiaris
?
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Cavia porcellus
?
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Homo sapiens
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mesocricetus auratus
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mus musculus
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Rattus norvegicus
More
structure molecular modeling
Canis lupus familiaris
More
structure molecular modeling
Cavia porcellus
More
structure molecular modeling
Homo sapiens
More
structure molecular modeling
Mesocricetus auratus
More
structure molecular modeling
Mus musculus
More
structure molecular modeling
Rattus norvegicus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Canis lupus familiaris
37
-
assay at
Cavia porcellus
37
-
assay at; assay at
Homo sapiens
37
-
assay at
Mesocricetus auratus
37
-
assay at
Mus musculus
37
-
assay at
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Canis lupus familiaris
7.4
-
assay at
Cavia porcellus
7.4
-
assay at; assay at
Homo sapiens
7.4
-
assay at
Mesocricetus auratus
7.4
-
assay at
Mus musculus
7.4
-
assay at
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
NADP+
-
Canis lupus familiaris
NADP+
-
Cavia porcellus
NADP+
-
Homo sapiens
NADP+
-
Mesocricetus auratus
NADP+
-
Mus musculus
NADP+
-
Rattus norvegicus
NADPH
-
Canis lupus familiaris
NADPH
-
Cavia porcellus
NADPH
-
Homo sapiens
NADPH
-
Mesocricetus auratus
NADPH
-
Mus musculus
NADPH
-
Rattus norvegicus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000006
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.000015
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.000025
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.000025
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.000028
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.00008
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.000082
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00011
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00012
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00012
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00023
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.00023
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.00025
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.00028
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00029
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0003
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.00033
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.00034
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.00035
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00043
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00044
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00055
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00059
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.00077
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00094
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0012
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0018
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.002
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0021
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.0021
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.0021
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0025
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.003
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0039
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0049
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.0049
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0052
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.0061
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0064
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.007
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.007
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0097
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.011
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.015
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.017
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.019
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.02
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.031
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.031
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.034
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.035
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.035
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.05
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.054
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.2
-
2'-hydroxyflavanone
above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.2
-
flavanone
above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
drug development
the enzyme is a target for inhibitor design and development
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Homo sapiens
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Mesocricetus auratus
expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells
Rattus norvegicus
expression of isozyme 11beta-HSD1 in HEK-293 cells
Cavia porcellus
isozyme 11beta-HSD1, expression in HEK-293 cells
Canis lupus familiaris
isozyme 11beta-HSD1, expression in HEK-293 cells
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
NADP+
-
Canis lupus familiaris
NADP+
-
Cavia porcellus
NADP+
-
Homo sapiens
NADP+
-
Mesocricetus auratus
NADP+
-
Mus musculus
NADP+
-
Rattus norvegicus
NADPH
-
Canis lupus familiaris
NADPH
-
Cavia porcellus
NADPH
-
Homo sapiens
NADPH
-
Mesocricetus auratus
NADPH
-
Mus musculus
NADPH
-
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2'-hydroxyflavanone
-
Canis lupus familiaris
2'-hydroxyflavanone
-
Cavia porcellus
2'-hydroxyflavanone
-
Homo sapiens
2'-hydroxyflavanone
-
Mesocricetus auratus
2'-hydroxyflavanone
-
Mus musculus
2'-hydroxyflavanone
-
Rattus norvegicus
abietic acid
-
Canis lupus familiaris
abietic acid
-
Cavia porcellus
abietic acid
-
Homo sapiens
abietic acid
-
Mesocricetus auratus
abietic acid
-
Mus musculus
abietic acid
-
Rattus norvegicus
carbenoxolone
-
Canis lupus familiaris
carbenoxolone
-
Cavia porcellus
carbenoxolone
-
Homo sapiens
carbenoxolone
-
Mesocricetus auratus
carbenoxolone
-
Mus musculus
carbenoxolone
-
Rattus norvegicus
chenodeoxycholic acid
-
Canis lupus familiaris
chenodeoxycholic acid
-
Cavia porcellus
chenodeoxycholic acid
-
Homo sapiens
chenodeoxycholic acid
-
Mesocricetus auratus
chenodeoxycholic acid
-
Mus musculus
chenodeoxycholic acid
-
Rattus norvegicus
flavanone
-
Canis lupus familiaris
flavanone
-
Cavia porcellus
flavanone
-
Homo sapiens
flavanone
-
Mesocricetus auratus
flavanone
-
Mus musculus
flavanone
-
Rattus norvegicus
glycyrrhetinic acid
-
Canis lupus familiaris
glycyrrhetinic acid
-
Cavia porcellus
glycyrrhetinic acid
-
Homo sapiens
glycyrrhetinic acid
-
Mesocricetus auratus
glycyrrhetinic acid
-
Mus musculus
glycyrrhetinic acid
-
Rattus norvegicus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Canis lupus familiaris
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Cavia porcellus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Homo sapiens
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Mesocricetus auratus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Mus musculus
additional information
inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL
Rattus norvegicus
T0504
-
Canis lupus familiaris
T0504
-
Cavia porcellus
T0504
-
Homo sapiens
T0504
-
Mesocricetus auratus
T0504
-
Mus musculus
T0504
-
Rattus norvegicus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.000006
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.000015
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.000025
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.000025
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.000028
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.00008
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.000082
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00011
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00012
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00012
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.00023
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.00023
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.00025
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.00028
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00029
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0003
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.00033
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.00034
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.00035
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00043
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00044
-
glycyrrhetinic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00055
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.00059
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.00077
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.00094
-
carbenoxolone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0012
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0018
-
T0504
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.002
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0021
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.0021
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.0021
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0025
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.003
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0039
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.0049
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.0049
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0052
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.0061
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.0064
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.007
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.007
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.0097
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.011
-
abietic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.015
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.017
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction
Homo sapiens
0.019
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.02
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.031
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Cavia porcellus
0.031
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction
Homo sapiens
0.034
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mus musculus
0.035
-
chenodeoxycholic acid
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Mesocricetus auratus
0.035
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Canis lupus familiaris
0.05
-
2'-hydroxyflavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.054
-
flavanone
pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation
Rattus norvegicus
0.2
-
2'-hydroxyflavanone
above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
0.2
-
flavanone
above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00038
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mus musculus
0.00042
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Homo sapiens
0.00043
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Cavia porcellus
0.00045
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mesocricetus auratus
0.00052
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Homo sapiens
0.00052
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mus musculus
0.00057
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Canis lupus familiaris
0.00057
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Mesocricetus auratus
0.00064
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Cavia porcellus
0.00085
-
11-Dehydrocorticosterone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Rattus norvegicus
0.00136
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Rattus norvegicus
0.00157
-
cortisone
pH 7.4, 37°C, recombinant isozyme 11beta-HSD1
Canis lupus familiaris
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
32000
-
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Cavia porcellus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mesocricetus auratus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mus musculus
33000
-
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Rattus norvegicus
35000
-
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Canis lupus familiaris
35000
-
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
11-dehydrocorticosterone + NADPH
Mus musculus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Rattus norvegicus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Canis lupus familiaris
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Mesocricetus auratus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Homo sapiens
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
11-dehydrocorticosterone + NADPH
Cavia porcellus
isozyme 11beta-HSD1
corticosterone + NADP+
-
-
?
cortisol + NAD+
Homo sapiens
isozyme 11beta-HSD2
cortisone + NADH
-
-
ir
cortisone + NADPH
Mus musculus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Rattus norvegicus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Canis lupus familiaris
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Mesocricetus auratus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Homo sapiens
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
cortisone + NADPH
Cavia porcellus
isozyme 11beta-HSD1, activation
cortisol + NADP+
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Canis lupus familiaris
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
-
Canis lupus familiaris
additional information
-
-
Cavia porcellus
additional information
-
-
Homo sapiens
additional information
-
-
Mesocricetus auratus
additional information
-
-
Mus musculus
additional information
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Mus musculus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Rattus norvegicus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Canis lupus familiaris
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Mesocricetus auratus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Homo sapiens
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1
669907
Cavia porcellus
corticosterone + NADP+
-
-
-
?
11-dehydrocorticosterone + NADPH
isozyme 11beta-HSD1, low activity
669907
Canis lupus familiaris
corticosterone + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Mus musculus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Rattus norvegicus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Homo sapiens
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction, very low activity
669907
Canis lupus familiaris
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction, very low activity
669907
Cavia porcellus
7beta-hydroxycholesterol + NADP+
-
-
-
?
7-oxocholesterol + NADPH
isozyme 11beta-HSD1, stereospecific reaction
669907
Mesocricetus auratus
7alpha-hydroxycholesterol + NADP+
-
-
-
?
cortisol + NAD+
isozyme 11beta-HSD2
669907
Homo sapiens
cortisone + NADH
-
-
-
ir
cortisol + NAD+
isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+
669907
Homo sapiens
cortisone + NADH
-
-
-
ir
cortisone + NADPH
isozyme 11beta-HSD1
669907
Mus musculus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1
669907
Rattus norvegicus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Mus musculus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Rattus norvegicus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Canis lupus familiaris
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Mesocricetus auratus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Homo sapiens
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, activation
669907
Cavia porcellus
cortisol + NADP+
-
-
-
?
cortisone + NADPH
isozyme 11beta-HSD1, high activity
669907
Mesocricetus auratus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, high activity
669907
Cavia porcellus
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, low activity
669907
Canis lupus familiaris
cortisol + NADP+
-
-
-
r
cortisone + NADPH
isozyme 11beta-HSD1, preferred substrate, high activity
669907
Homo sapiens
cortisol + NADP+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Canis lupus familiaris
?
x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Cavia porcellus
?
x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Homo sapiens
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mesocricetus auratus
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Mus musculus
?
x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE
Rattus norvegicus
More
structure molecular modeling
Canis lupus familiaris
More
structure molecular modeling
Cavia porcellus
More
structure molecular modeling
Homo sapiens
More
structure molecular modeling
Mesocricetus auratus
More
structure molecular modeling
Mus musculus
More
structure molecular modeling
Rattus norvegicus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Canis lupus familiaris
37
-
assay at
Cavia porcellus
37
-
assay at
Homo sapiens
37
-
assay at
Mesocricetus auratus
37
-
assay at
Mus musculus
37
-
assay at
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Canis lupus familiaris
7.4
-
assay at
Cavia porcellus
7.4
-
assay at
Homo sapiens
7.4
-
assay at
Mesocricetus auratus
7.4
-
assay at
Mus musculus
7.4
-
assay at
Rattus norvegicus
Other publictions for EC 1.1.1.B40
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
726314
Hu
Curcumin as a potent and selec ...
Homo sapiens
PLoS ONE
8
e49976
2013
-
-
-
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1
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-
-
-
-
-
-
-
-
725817
Kratschmar
Characterization of activity a ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
125
129-142
2011
-
-
1
-
-
-
4
-
-
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-
-
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1
-
-
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1
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1
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2
4
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1
-
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-
-
-
-
725818
Zhao
The inhibition of human and ra ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
125
143-147
2011
-
-
-
-
-
-
2
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2
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-
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-
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-
-
-
-
697286
Zhao
Structure-dependent inhibition ...
Homo sapiens, Rattus norvegicus
Chem. Biol. Interact.
183
79-84
2010
-
-
-
-
-
-
16
-
2
-
-
-
-
4
-
-
-
-
-
2
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-
2
-
-
-
-
-
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-
2
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-
5
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-
2
-
-
-
5
16
-
-
2
-
-
-
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-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711471
Stanetty
Synthesis of novel 3-amino and ...
Homo sapiens
Bioorg. Med. Chem.
18
7522-7541
2010
-
-
1
-
-
-
27
-
-
-
-
-
-
1
-
-
-
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-
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-
1
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1
-
-
27
-
-
1
1
-
-
-
27
27
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-
1
-
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-
-
-
-
711694
Kim
Selection and optimization of ...
Homo sapiens
Cell Biochem. Funct.
28
440-447
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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2
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1
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-
1
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-
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-
1
1
-
-
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-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713232
Zhang
Rare merosesquiterpenoids from ...
Homo sapiens
Phytochemistry
71
100-103
2010
-
-
1
-
-
-
5
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
5
-
-
1
1
-
-
-
5
5
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696054
Hong
Mono-(2-ethylhexyl) phthalate ...
Mus musculus
Biochem. Biophys. Res. Commun.
389
305-309
2009
-
-
-
-
-
-
1
-
1
-
1
1
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
1
-
-
-
2
1
-
-
1
-
1
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697720
Mericq
Differences in expression and ...
Homo sapiens
Eur. J. Endocrinol.
161
419-425
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699841
Chen
The (+)- and (-)-gossypols pot ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
113
177-181
2009
-
-
-
-
-
-
8
-
-
-
-
2
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
8
-
-
-
2
-
-
-
8
8
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699842
Classen-Houben
Selective inhibition of 11beta ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
113
248-252
2009
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
699847
Sharp
Expression and activities of 1 ...
Sus scrofa
J. Steroid Biochem. Mol. Biol.
115
98-106
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700178
Chapman
The role and regulation of 11b ...
Homo sapiens, Mus musculus
Mol. Cell. Endocrinol.
301
123-131
2009
2
1
-
-
-
-
2
-
-
-
-
2
-
2
-
-
-
-
-
15
-
-
2
-
-
-
-
-
-
-
-
2
-
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-
2
1
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
15
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711737
Xu
Sesquiterpenes from cultures o ...
Homo sapiens, Mus musculus
Chem. Pharm. Bull.
57
433-435
2009
-
-
2
-
-
-
7
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
7
-
-
2
2
-
-
-
7
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712257
Zhang
Pentanol derivatives from basi ...
Homo sapiens, Mus musculus
J. Antibiot.
62
239-242
2009
-
-
2
-
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
2
-
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-
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-
-
-
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2
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-
5
-
-
2
2
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686234
Sadosky
Increased production of 11beta ...
Oryctolagus cuniculus, Saimiri, Sus scrofa
Comp. Med.
58
180-187
2008
-
1
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687317
Balazs
DHEA induces 11 -HSD2 by actin ...
Rattus norvegicus
J. Am. Soc. Nephrol.
19
92-101
2008
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687328
Ito-Kobayashi
Sterenin A, B, C and D, novel ...
Homo sapiens
J. Antibiot.
61
128-135
2008
-
-
1
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
688010
Sloboda
Expression of glucocorticoid r ...
Ovis aries
J. Endocrinol.
197
213-220
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688766
Gong
Human renal 11beta-hydroxyster ...
Homo sapiens
Life Sci.
82
631-637
2008
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693544
Johansson
2-amino-1,3-thiazol-4(5H)-ones ...
Homo sapiens
J. Med. Chem.
51
2933-2943
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693882
Honda
Leydig cells from neonatal pig ...
Sus scrofa
J. Steroid Biochem. Mol. Biol.
108
91-101
2008
-
-
-
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694281
Sakumoto
Changes in expression of 11bet ...
Sus scrofa
Mol. Reprod. Dev.
75
925-930
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695148
Klusonova
Chicken 11beta-hydroxysteroid ...
Gallus gallus
Steroids
73
348-355
2008
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
8
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695443
Henschkowski
Age-dependent decrease in 11be ...
Homo sapiens
Am. J. Hypertens.
21
644-649
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701239
Gong
Variable expression of 11beta ...
Bos taurus, Homo sapiens, Rattus norvegicus
Steroids
73
1187-1196
2008
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
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3
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11
-
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-
-
-
-
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-
-
-
-
-
-
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687961
Jang
Altered activity of 11beta-hyd ...
Homo sapiens
J. Clin. Endocrinol. Metab.
92
3314-3320
2007
1
1
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1
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1
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1
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-
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-
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-
-
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689337
Garbrecht
11-beta Hydroxysteroid dehydro ...
Homo sapiens
Pediatr. Res.
62
26-31
2007
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-
-
-
-
-
2
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-
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1
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1
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1
-
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-
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-
-
-
-
-
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-
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-
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-
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-
693380
Chandras
PTGER1 and PTGER2 receptors me ...
Homo sapiens
J. Endocrinol.
194
595-602
2007
1
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-
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693880
Milagro
11-Beta hydroxysteroid dehydro ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
104
81-84
2007
-
1
-
-
-
-
-
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4
-
-
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-
1
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1
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1
-
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-
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-
-
-
-
-
-
-
-
-
-
-
695090
Sharp
11Beta-hydroxysteroid dehydrog ...
Sus scrofa
Reproduction
134
473-482
2007
-
-
-
-
-
-
-
3
-
-
1
1
-
1
-
-
-
-
-
9
-
-
3
1
-
-
-
-
-
-
-
1
-
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-
-
-
-
1
-
-
-
-
-
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3
-
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1
1
-
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-
-
9
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667151
Kossintseva
Proinflammatory cytokines inhi ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
290
E282-E288
2006
-
-
-
-
-
-
6
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
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-
1
-
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-
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-
1
-
-
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6
-
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2
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667152
Garbrecht
11beta-Hydroxysteroid dehydrog ...
Homo sapiens
Am. J. Physiol. Endocrinol. Metab.
290
E653-E660
2006
-
-
-
-
-
-
1
-
1
-
1
2
-
1
-
-
-
-
-
3
-
-
3
1
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
1
2
-
-
-
-
-
3
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668297
Jang
11beta Hydroxysteroid dehydrog ...
Homo sapiens
Clin. Endocrinol. (Oxf.)
65
800-805
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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-
1
-
-
-
-
-
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-
-
1
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-
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-
1
-
-
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-
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-
1
-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668379
Basu
Splanchnic cortisol production ...
Canis lupus familiaris
Diabetes
55
3013-3019
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
4
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668425
Groyer
Expression and functional stat ...
Rattus norvegicus
Endocrinology
147
4339-4350
2006
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
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-
-
1
-
-
-
-
-
2
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
668426
Ozaki
Roles of 11beta-hydroxysteroid ...
Anguilla japonica
Endocrinology
147
5139-5146
2006
2
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670896
Temkin
-
Type 2 11beta-hydroxysteroid d ...
Homo sapiens
Steroids
7
1019-1023
2006
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667203
Denari
Seasonal changes in the activi ...
Rhinella arenarum
Ann. N. Y. Acad. Sci.
1040
297-300
2005
-
-
-
-
-
-
1
3
3
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
3
3
-
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667673
Zhang
Crystal structure of murine 11 ...
Mus musculus
Biochemistry
44
6948-6957
2005
-
1
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667956
Xiang
Synthesis and biological evalu ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
2865-2869
2005
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667962
Olson
Adamantyl triazoles as selecti ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem. Lett.
15
4359-4362
2005
-
-
-
-
-
-
24
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
24
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668432
Ohshima
Inhibitory effects of some pos ...
Homo sapiens
Environ. Sci.
12
219-230
2005
-
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668505
Claus
Characterization of 11beta-hyd ...
Sus scrofa
Exp. Clin. Endocrinol. Diabetes
113
262-267
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
669706
Carvajal
Biochemical and genetic charac ...
Homo sapiens
J. Hypertens.
23
71-77
2005
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669907
Arampatzis
Comparative enzymology of 11be ...
Canis lupus familiaris, Cavia porcellus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
J. Mol. Endocrinol.
35
89-101
2005
-
1
6
-
-
-
48
12
-
-
6
13
-
7
-
-
-
6
-
1
6
-
27
12
6
-
-
-
6
-
-
13
56
-
-
-
2
6
13
-
-
-
-
55
56
12
-
-
6
13
-
-
-
-
-
1
7
-
27
12
7
-
-
-
7
-
-
-
-
-
-
-
-
-
670034
Mazancova
11beta-Hydroxysteroid dehydrog ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
94
273-277
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670252
Latif
Endogenous selective inhibitor ...
Ovis aries
Mol. Cell. Endocrinol.
243
43-50
2005
-
-
-
-
-
-
18
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
15
-
-
-
-
-
-
-
15
18
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
654889
Schipper
Characterisation of 11beta-hyd ...
Felis catus
Biochim. Biophys. Acta
1688
68-77
2004
-
-
-
-
-
-
-
1
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
655162
Zbankova
Expression of 11beta-hydroxyst ...
Homo sapiens
Cancer Lett.
210
95-100
2004
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656350
Zallocchi
Adrenal gland involvement in t ...
Rattus norvegicus
J. Cell. Biochem.
92
591-602
2004
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654171
Gomez-Sanchez
Regulation of 11beta-hydroxyst ...
Rattus norvegicus
Am. J. Physiol.
285
E272-279
2003
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654196
Holmes
11beta-Hydroxysteroid dehydrog ...
Mus musculus, Rattus norvegicus
Ann. N. Y. Acad. Sci.
1007
357-366
2003
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
8
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
8
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655349
Waddell
Localization of 11beta-hydroxy ...
Rattus norvegicus
Endocrinology
144
3101-3106
2003
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667148
Gomez-Sanchez
Regulation of 11beta-hydroxyst ...
Rattus norvegicus
Am. J. Physiol. Endocrinol. Metab.
285
E272-E279
2003
-
-
-
-
-
-
2
-
-
-
-
2
-
4
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
656372
Burton
Myometrial expression of 11bet ...
Rattus norvegicus
J. Endocrinol.
172
519-526
2002
-
-
-
-
-
-
1
3
-
-
1
1
-
3
-
-
-
-
-
4
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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1
1
3
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1
1
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1
1
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Selective inhibition of sheep ...
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21
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2
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285949
Ferrari
Substrate and inhibitor specif ...
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2
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1
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3
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1
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3
6
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1
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2
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285950
Alfaidy
Characteristics and regulation ...
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1
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1
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1
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5
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285951
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Characterization of human plac ...
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2
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1
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2
2
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1
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1
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1
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1
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285953
Albiston
Cloning and tissue distributio ...
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9
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4
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285954
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10
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1
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10
10
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Characterization of 11beta-hyd ...
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4
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2
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1
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285956
Monder
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1
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1
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3
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285957
Naray-Fejes-Toth
Expression and characterizatio ...
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285958
Hundertmark
11-beta-Hydroxysteroid dehydro ...
Rattus norvegicus
Enzyme Protein
47
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1993
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