Literature summary for 1.1.1.B40 extracted from

Burton, P.J.; Waddell, B.J.
Myometrial expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy (2002), J. Endocrinol., 172, 519-526.

Search for more literature for 1.1.1.B40

Inhibitors

Inhibitors	Comment	Organism	Structure
progesterone	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.000047	-	corticosterone	37°C, in non-pregnant myometrium	Rattus norvegicus
0.00006	-	corticosterone	37°C, after day 23 of pregnancy	Rattus norvegicus
0.000075	-	corticosterone	37°C, after day 10 of pregnancy	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	x * 40000, immunoblot	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
corticosterone + NAD+	Rattus norvegicus	-	11-dehydrocorticosterone + NADH + H+	-	ir

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
myometrium	-	Rattus norvegicus	-
uterus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
corticosterone + NAD+	-	Rattus norvegicus	11-dehydrocorticosterone + NADH + H+	-	ir

Subunits

Subunits	Comment	Organism
?	x * 40000, immunoblot	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
11beta-hydroxysteroid dehydrogenase type 2	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0018	-	progesterone	probably minimal physiological importance	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)