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Literature summary for 1.1.1.B40 extracted from
- 11beta-Hydroxysteroid dehydrogenases in the brain: two enzymes two roles (2003), Ann. N. Y. Acad. Sci., 1007, 357-366.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | Mus musculus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir |  |
| corticosterone + NAD+ | Rattus norvegicus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | 11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone | Mus musculus | - |
| brain | 11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone | Rattus norvegicus | - |
| cerebellum | - |
Mus musculus | - |
| cerebellum | - |
Rattus norvegicus | - |
| hippocampus | - |
Mus musculus | - |
| hippocampus | - |
Rattus norvegicus | - |
| neocortex | - |
Mus musculus | - |
| neocortex | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | - |
Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
| corticosterone + NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Mus musculus |
| 11beta-HSD2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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