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Literature summary for 1.1.1.B40 extracted from

  • Hundertmark, S.; Ragosch, V.; Schein, B.; Buhler, H.; Fromm, M.; Lorenz, U.; Weitzel, H.K.
    11-beta-Hydroxysteroid dehydrogenase of rat lung: Enzyme kinetic, oxidase-reductase ration, electrolyte and trace element dependence (1993), Enzyme Protein, 47, 83-91.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADP+ 50% inhibition at 220 nmol Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00108
-
11beta,21-dihydroxypregn-4-en-3,20-dione temperature not specified in the publication, pH 9 Rattus norvegicus
0.091
-
NAD+ temperature not specified in the publication, pH 9 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Rattus norvegicus i.e. corticosterone, no enzyme activity in reverse reaction direction 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung fetal, adult Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 0.01 M sodium phosphate, pH 7.4, 0.25 M sucrose, 6 weeks Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone, no enzyme activity in reverse reaction direction Rattus norvegicus 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
ir

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
reductase activity Rattus norvegicus
9
-
oxidase activity Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
additional information NADH, no substrate affinity Rattus norvegicus
NAD+ 20 times lower affinity than for NADP+ Rattus norvegicus