BRENDA - Enzyme Database show
show all sequences of 1.1.1.B3

Purification and characterization of an enantioselective carbonyl reductase from Candida viswanathii MTCC 5158

Soni, P.; Kansal, H.; Banerjee, U.C.; Process Biochem. 42, 1632-1640 (2007)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
2 mM, 115% of initial activity
Candida viswanathii
Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxy mercuribenzoate
2 mM, 5% residual activity
Candida viswanathii
AgNO3
2 mM, complete inhibition
Candida viswanathii
citrate
2 mM, 28% residual activity
Candida viswanathii
Co(NO3)2
2 mM, 59% residual activity
Candida viswanathii
CuSO4
2 mM, complete inhibition
Candida viswanathii
D-Cysteine
2 mM, 8% residual activity
Candida viswanathii
diethyldicarbonate
2 mM, 30% residual activity
Candida viswanathii
EDTA
2 mM, 49% residual activity
Candida viswanathii
FeCl3
2 mM, 2% residual activity
Candida viswanathii
glutathione
2 mM, 31% residual activity
Candida viswanathii
guanidinium hydrochloride
1 M, 1.5% residual activity
Candida viswanathii
hydroxylamine
2 mM, 23% residual activity
Candida viswanathii
Hydroxyquinoline
2 mM, 18% residual activity
Candida viswanathii
L-cysteine
2 mM, 12% residual activity
Candida viswanathii
MgCl2
2 mM, 75% residual activity
Candida viswanathii
MnSO4
2 mM, 53% residual activity
Candida viswanathii
additional information
not inhibitory at 2 mM: BaCl2, CaCO3, NaCl
Candida viswanathii
N-ethylmaleimide
2 mM, 5% residual activity
Candida viswanathii
NiCl2
2 mM, 24% residual activity
Candida viswanathii
o-phenanthroline
2 mM, 9% residual activity
Candida viswanathii
oxalate
2 mM, 26% residual activity
Candida viswanathii
Pb(OAc)2
2 mM, 8% residual activity
Candida viswanathii
potassium iodide
1 M, 1.4% residual activity
Candida viswanathii
Sodium azide
2 mM, 35% residual activity
Candida viswanathii
sodium dodecylsulfate
1% w/v, 6% residual activity
Candida viswanathii
tartarate
2 mM, 21% residual activity
Candida viswanathii
Triton X-100
1% w/v, 67% residual activity
Candida viswanathii
Tween 80
1% w/v, 26.5% residual activity
Candida viswanathii
Urea
1 M, 5.8% residual activity
Candida viswanathii
ZnSO4
2 mM, 2% residual activity
Candida viswanathii
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.153
-
acetophenone
pH 7.0, 25°C
Candida viswanathii
0.157
-
NADH
pH 7.0, 25°C
Candida viswanathii
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29000
-
4 * 29000, SDS-PAGE
Candida viswanathii
120000
-
gel filtration
Candida viswanathii
Organic Solvent Stability
Organic Solvent
Commentary
Organism
dimethyl formamide
15% v/v, 16% residual activity
Candida viswanathii
dimethyl sulfoxide
15% v/v, 16% residual activity
Candida viswanathii
dioxane
34% v/V, 16% residual activity
Candida viswanathii
Ethanol
15% v/v, 48% residual activity
Candida viswanathii
isopropanol
15% v/v, 2.5% residual activity
Candida viswanathii
Pyridine
15% v/v, 0.4% residual activity
Candida viswanathii
tetrahydrofuran
15% v/v, 11% residual activity
Candida viswanathii
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Candida viswanathii
-
strain MTCC 5158
-
Candida viswanathii MTCC 5158
-
strain MTCC 5158
-
Purification (Commentary)
Commentary
Organism
-
Candida viswanathii
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
358.6
-
pH 7.0, 25°C
Candida viswanathii
Storage Stability
Storage Stability
Organism
-20°C, phosphate buffer, pH 7.0, presence of 2-mercaptoethanol and phenylmethyl sulfonylfluoride, stable for at least 3 months
Candida viswanathii
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(2-fluorophenyl)ethanol + NAD+
-
-
-
?
2'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(2-fluorophenyl)ethanol + NAD+
-
-
-
?
3'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(3-fluorophenyl)ethanol + NAD+
-
-
-
?
3'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(3-fluorophenyl)ethanol + NAD+
-
-
-
?
4'-acetoxy acetophenone + NADH + H+
80% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-acetoxyphenyl)ethanol + NAD+
-
-
-
?
4'-acetoxy acetophenone + NADH + H+
80% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(4-acetoxyphenyl)ethanol + NAD+
-
-
-
?
4'-acetyl pyridine + NADH + H+
98% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(pyridin-4-yl)ethanol + NAD+
102% of the activity with acetophenone, enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
4'-acetyl pyridine + NADH + H+
98% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(pyridin-4-yl)ethanol + NAD+
102% of the activity with acetophenone, enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
4'-bromoacetophenone + NADH + H+
82% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-bromophenyl)ethanol + NAD+
-
-
-
?
4'-bromoacetophenone + NADH + H+
82% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(4-bromophenyl)ethanol + NAD+
-
-
-
?
4'-chloroacetophenone + NADH + H+
83% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-chlorophenyl)ethanol + NAD+
-
-
-
?
4'-fluoroacetophenone + NADH + H+
117% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-fluorophenyl)ethanol + NAD+
-
-
-
?
4'-iodoacetophenone + NADH + H+
31% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-iodophenyl)ethanol + NAD+
-
-
-
?
acetophenone + NADH + H+
-
689823
Candida viswanathii
(1S)-1-phenylethanol + NAD+
enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
Subunits
Subunits
Commentary
Organism
tetramer
4 * 29000, SDS-PAGE
Candida viswanathii
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Candida viswanathii
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
20
-
54% of maximum activity
Candida viswanathii
75
-
61% of maximum activity
Candida viswanathii
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
25
-
phosphate buffer, pH 7.0, 7 h, 80% residual activity
Candida viswanathii
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Candida viswanathii
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.5
7
more than 80% of maximum activity
Candida viswanathii
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Candida viswanathii
NADH
-
Candida viswanathii
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
2-mercaptoethanol
2 mM, 115% of initial activity
Candida viswanathii
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Candida viswanathii
NADH
-
Candida viswanathii
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxy mercuribenzoate
2 mM, 5% residual activity
Candida viswanathii
AgNO3
2 mM, complete inhibition
Candida viswanathii
citrate
2 mM, 28% residual activity
Candida viswanathii
Co(NO3)2
2 mM, 59% residual activity
Candida viswanathii
CuSO4
2 mM, complete inhibition
Candida viswanathii
D-Cysteine
2 mM, 8% residual activity
Candida viswanathii
diethyldicarbonate
2 mM, 30% residual activity
Candida viswanathii
EDTA
2 mM, 49% residual activity
Candida viswanathii
FeCl3
2 mM, 2% residual activity
Candida viswanathii
glutathione
2 mM, 31% residual activity
Candida viswanathii
guanidinium hydrochloride
1 M, 1.5% residual activity
Candida viswanathii
hydroxylamine
2 mM, 23% residual activity
Candida viswanathii
Hydroxyquinoline
2 mM, 18% residual activity
Candida viswanathii
L-cysteine
2 mM, 12% residual activity
Candida viswanathii
MgCl2
2 mM, 75% residual activity
Candida viswanathii
MnSO4
2 mM, 53% residual activity
Candida viswanathii
additional information
not inhibitory at 2 mM: BaCl2, CaCO3, NaCl
Candida viswanathii
N-ethylmaleimide
2 mM, 5% residual activity
Candida viswanathii
NiCl2
2 mM, 24% residual activity
Candida viswanathii
o-phenanthroline
2 mM, 9% residual activity
Candida viswanathii
oxalate
2 mM, 26% residual activity
Candida viswanathii
Pb(OAc)2
2 mM, 8% residual activity
Candida viswanathii
potassium iodide
1 M, 1.4% residual activity
Candida viswanathii
Sodium azide
2 mM, 35% residual activity
Candida viswanathii
sodium dodecylsulfate
1% w/v, 6% residual activity
Candida viswanathii
tartarate
2 mM, 21% residual activity
Candida viswanathii
Triton X-100
1% w/v, 67% residual activity
Candida viswanathii
Tween 80
1% w/v, 26.5% residual activity
Candida viswanathii
Urea
1 M, 5.8% residual activity
Candida viswanathii
ZnSO4
2 mM, 2% residual activity
Candida viswanathii
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.153
-
acetophenone
pH 7.0, 25°C
Candida viswanathii
0.157
-
NADH
pH 7.0, 25°C
Candida viswanathii
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29000
-
4 * 29000, SDS-PAGE
Candida viswanathii
120000
-
gel filtration
Candida viswanathii
Organic Solvent Stability (protein specific)
Organic Solvent
Commentary
Organism
dimethyl formamide
15% v/v, 16% residual activity
Candida viswanathii
dimethyl sulfoxide
15% v/v, 16% residual activity
Candida viswanathii
dioxane
34% v/V, 16% residual activity
Candida viswanathii
Ethanol
15% v/v, 48% residual activity
Candida viswanathii
isopropanol
15% v/v, 2.5% residual activity
Candida viswanathii
Pyridine
15% v/v, 0.4% residual activity
Candida viswanathii
tetrahydrofuran
15% v/v, 11% residual activity
Candida viswanathii
Purification (Commentary) (protein specific)
Commentary
Organism
-
Candida viswanathii
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
358.6
-
pH 7.0, 25°C
Candida viswanathii
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, phosphate buffer, pH 7.0, presence of 2-mercaptoethanol and phenylmethyl sulfonylfluoride, stable for at least 3 months
Candida viswanathii
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(2-fluorophenyl)ethanol + NAD+
-
-
-
?
2'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(2-fluorophenyl)ethanol + NAD+
-
-
-
?
3'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(3-fluorophenyl)ethanol + NAD+
-
-
-
?
3'-fluoroacetophenone + NADH + H+
102% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(3-fluorophenyl)ethanol + NAD+
-
-
-
?
4'-acetoxy acetophenone + NADH + H+
80% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-acetoxyphenyl)ethanol + NAD+
-
-
-
?
4'-acetoxy acetophenone + NADH + H+
80% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(4-acetoxyphenyl)ethanol + NAD+
-
-
-
?
4'-acetyl pyridine + NADH + H+
98% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(pyridin-4-yl)ethanol + NAD+
102% of the activity with acetophenone, enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
4'-acetyl pyridine + NADH + H+
98% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(pyridin-4-yl)ethanol + NAD+
102% of the activity with acetophenone, enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
4'-bromoacetophenone + NADH + H+
82% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-bromophenyl)ethanol + NAD+
-
-
-
?
4'-bromoacetophenone + NADH + H+
82% of the activity with acetophenone
689823
Candida viswanathii MTCC 5158
(1S)-1-(4-bromophenyl)ethanol + NAD+
-
-
-
?
4'-chloroacetophenone + NADH + H+
83% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-chlorophenyl)ethanol + NAD+
-
-
-
?
4'-fluoroacetophenone + NADH + H+
117% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-fluorophenyl)ethanol + NAD+
-
-
-
?
4'-iodoacetophenone + NADH + H+
31% of the activity with acetophenone
689823
Candida viswanathii
(1S)-1-(4-iodophenyl)ethanol + NAD+
-
-
-
?
acetophenone + NADH + H+
-
689823
Candida viswanathii
(1S)-1-phenylethanol + NAD+
enantiomeric excess of more than 99% for (S)-configuration of product
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
tetramer
4 * 29000, SDS-PAGE
Candida viswanathii
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Candida viswanathii
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
20
-
54% of maximum activity
Candida viswanathii
75
-
61% of maximum activity
Candida viswanathii
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
25
-
phosphate buffer, pH 7.0, 7 h, 80% residual activity
Candida viswanathii
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Candida viswanathii
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.5
7
more than 80% of maximum activity
Candida viswanathii
Other publictions for EC 1.1.1.B3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724568
Cao
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1
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-
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3
1
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-
-
-
3
1
-
-
1
-
-
-
1
-
5
-
1
2
-
-
1
1
2
2
-
-
-
-
1
1
2
-
-
-
-
3
-
1
-
-
-
-
3
-
-
1
-
-
1
-
5
-
1
2
-
-
1
1
2
-
-
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-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725726
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Deracemization of aryl seconda ...
Rhodotorula sp., Rhodotorula sp. AS2.2241
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-
1
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697267
Pal
Activity of yeast alcohol dehy ...
Saccharomyces carlsbergensis, Saccharomyces carlsbergensis Y379-50, Saccharomyces cerevisiae
Chem. Biol. Interact.
178
16-23
2009
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697839
Pennacchio
Role of Tryptophan 95 in subst ...
Sulfolobus solfataricus
Extremophiles
13
751-761
2009
-
-
1
1
1
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
4
-
-
-
1
-
-
-
-
-
1
1
1
1
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
701031
Rocha-Martin
-
Purification, immobilization a ...
Thermus thermophilus
Process Biochem.
44
1004-1012
2009
-
1
1
-
1
-
-
-
-
-
1
1
-
1
-
-
1
-
-
-
1
-
2
1
1
-
3
-
1
-
1
2
-
-
-
-
1
1
2
-
1
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
1
-
2
1
1
-
3
-
1
-
1
-
-
-
-
-
-
-
684583
Pennacchio
Purification and characterizat ...
Thermus thermophilus
Appl. Environ. Microbiol.
74
3949-3958
2008
1
1
1
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7
6
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5
4
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1
5
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1
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1
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7
1
2
1
4
5
2
2
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3
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1
1
1
3
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7
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6
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5
4
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1
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1
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7
1
2
1
4
5
2
2
-
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689823
Soni
-
Purification and characterizat ...
Candida viswanathii, Candida viswanathii MTCC 5158
Process Biochem.
42
1632-1640
2007
1
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30
2
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2
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7
3
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1
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1
1
14
1
1
2
1
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1
1
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2
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1
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2
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30
-
2
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2
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7
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1
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1
1
14
1
1
2
1
-
1
1
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685078
Hoeffken
Crystal structure and enzyme k ...
uncultured bacterium, uncultured bacterium EbN1
Biochemistry
45
82-93
2006
-
-
1
1
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3
3
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3
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2
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1
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4
1
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1
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1
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3
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3
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3
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1
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4
1
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684588
Abokitse
Cloning, sequence analysis, an ...
Rhodococcus erythropolis
Appl. Microbiol. Biotechnol.
62
380-386
2003
-
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1
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2
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1
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1
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1
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1
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1
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1
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5
1
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-
685641
Yamamoto
-
Synthesis of (R)-1,3-butanedio ...
Candida parapsilosis
Biosci. Biotechnol. Biochem.
4
925-927
2002
-
1
1
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-
-
-
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-
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1
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1
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2
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1
1
2
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1
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685644
Yamamoto
Synthesis of ethyl (R)-4-chlor ...
Candida parapsilosis
Biosci. Biotechnol. Biochem.
66
481-483
2002
-
1
1
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3
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1
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1
1
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1
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-
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-
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685643
Xie
NAD+-Dependent (S)-specific se ...
Nocardia fusca AKU 2123
Biosci. Biotechnol. Biochem.
63
1721-1729
1999
-
-
-
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7
3
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2
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4
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1
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1
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24
1
2
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2
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2
1
3
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3
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7
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3
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2
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1
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1
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24
1
2
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2
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2
1
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