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Literature summary for 1.1.1.96 extracted from

  • Zannoni, V.G.; Weber, W.W.
    Isolation and properties of aromatic alpha-keto acid reductase (1966), J. Biol. Chem., 241, 1340-1344.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,5-dihydroxybenzoic acid 1 mM, 44% inhibition Bos taurus
2,5-dihydroxyphenyllactic acid 1 mM, 20% inhibition Bos taurus
3,5-Diiodo-4-hydroxyphenyllactic acid 1 mM, 18% inhibition Bos taurus
3,5-diiodotyrosine 1 mM, 15% inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.043
-
3,5-diiodo-4-hydroxyphenylpyruvate
-
Bos taurus
0.052
-
NADH
-
Bos taurus
1.9
-
4-hydroxyphenylpyruvate
-
Bos taurus
4.8
-
phenylpyruvate
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, calcium phosphate gel Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Cavia porcellus
-
blood
-
Cavia porcellus
-
brain
-
Cavia porcellus
-
brain
-
Canis lupus familiaris
-
heart
-
Cavia porcellus
-
heart
-
Bos taurus
-
heart
-
Canis lupus familiaris
-
kidney
-
Cavia porcellus
-
kidney
-
Canis lupus familiaris
-
liver
-
Cavia porcellus
-
liver
-
Canis lupus familiaris
-
muscle
-
Cavia porcellus
-
thyroid gland
-
Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
41.75
-
-
Bos taurus

Storage Stability

Storage Stability Organism
5°C, 160 mM phosphate, pH 6.5, 1 month, 20% activity lost Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5-dinitro-4-hydroxyphenylpyruvate + NADH
-
Bos taurus 3,5-dinitro-4-hydroxyphenyllactate + NAD+
-
r
3-(3,5-dibromo-4-hydroxyphenyl)pyruvate + NADH
-
Bos taurus 3-(3,5-dibromo-4-hydroxyphenyl)lactate + NAD+
-
r
3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH
-
Canis lupus familiaris 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+
-
r
3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH formation of phenyllactic acids is strongly favoured Bos taurus 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+
-
r
3-bromo-4-hydroxyphenylpyruvate + NADH
-
Bos taurus 3-bromo-4-hydroxyphenyllactate + NAD+
-
r
3-fluorophenylpyruvate + NADH
-
Bos taurus 3-fluorophenyllactate + NAD+
-
r
4-hydroxyphenylpyruvate + NADH + H+
-
Bos taurus 4-hydroxyphenyllactate + NAD+
-
r
indolepyruvate + NADH
-
Bos taurus indolelactate + NAD+
-
r
indolepyruvate + NADH
-
Canis lupus familiaris indolelactate + NAD+
-
r
phenylpyruvate + NADH
-
Bos taurus phenyllactate + NAD+
-
r
phenylpyruvate + NADH
-
Canis lupus familiaris phenyllactate + NAD+
-
r

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
62
-
not completely inactivated after 2 min, completely inactivated above 72°C Bos taurus
72
-
complete inactivation in 2 min Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus
NADH
-
Canis lupus familiaris
NADPH 15% activity compared to NADH Bos taurus