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Literature summary for 1.1.1.91 extracted from

  • Sloane, N.H.
    Metabolites of p-aminobenzoic acid. 5. Isolation and properties of p-aminobenzyl alcohol dehydrogenase (1973), Biochim. Biophys. Acta, 327, 11-19.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Mycobacterium tuberculosis
p-chloromercuribenzoate
-
 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 p-aminobenzyl alcohol
-
 Mycobacterium tuberculosis
0.057
-
 benzyl alcohol
-
 Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
 American Type Culture Collection No.607
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyl alcohol + NADP+
-
 Mycobacterium tuberculosis benzaldehyde + NADPH
-
 r
p-aminobenzyl alcohol + NADP+
-
 Mycobacterium tuberculosis p-aminobenzaldehyd + NADPH
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 in imidazole buffer Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
6.2 7.2 in imidazole buffer Mycobacterium tuberculosis
7 8 in phosphate buffer, activity of the enzyme is only one-half that shown in imidazole buffer Mycobacterium tuberculosis
7.9 8.5 in Tris buffer, activity is about 40% as in imidazole buffer Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+ enzyme utizilizes either NAD+ or NADP+ in the oxidation Mycobacterium tuberculosis
NADP+ enzyme utizilizes either NAD+ or NADP+ in the oxidation Mycobacterium tuberculosis
NADPH
-
 Mycobacterium tuberculosis