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Purification and characterization of xylitol dehydrogenase with L-arabitol dehydrogenase activity from the newly isolated pentose-fermenting yeast Meyerozyma caribbica 5XY2

Sukpipat, W.; Komeda, H.; Prasertsan, P.; Asano, Y.; J. Biosci. Bioeng. 123, 20-27 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene xyl2, DNA and amino acid sequence determination and analysis, cloning in Escherichia coli strain JM109, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
Meyerozyma caribbica
Inhibitors
Inhibitors
Commentary
Organism
Structure
EDTA
-
Meyerozyma caribbica
iodoacetic acid
-
Meyerozyma caribbica
o-phenanthroline
-
Meyerozyma caribbica
Tiron
-
Meyerozyma caribbica
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.1
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
0.11
-
NAD+
at pH 7.0 and 30°C
Meyerozyma caribbica
0.11
-
xylitol
native enzyme, pH 7.0, 30°C
Meyerozyma caribbica
15.4
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
15.8
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
16
-
xylitol
native enzyme, pH 7.0, 30°C
Meyerozyma caribbica
16.1
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
21.2
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
31.1
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
zinc metalloenzyme
Meyerozyma caribbica
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
195000
-
gel filtration
Meyerozyma caribbica
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
xylitol + NAD+
Meyerozyma caribbica
-
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica
preferred substrate
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica 5XY2
preferred substrate
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica 5XY2
-
D-xylulose + NADH + H+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Meyerozyma caribbica
A0A1B4XTS0
pentose-fermenting strain isolated from an alcohol fermentation starter in Thailand
-
Meyerozyma caribbica
-
-
-
Meyerozyma caribbica 5XY2
A0A1B4XTS0
pentose-fermenting strain isolated from an alcohol fermentation starter in Thailand
-
Meyerozyma caribbica 5XY2
-
-
-
Purification (Commentary)
Commentary
Organism
DEAEToyopearl 650 M column chromatography, butyl-Toyopearl 650 M column chromatography, MonoQ column chromatography, and Superdex 200 gel filtration; native enzyme by ammonium sulfate fractionation, anion exchange chromatography, hydrophobic interation chromatography, and another different step of anion exchange chromatography, followed by gel filtration. Recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity and anion exchange chromatography
Meyerozyma caribbica
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
strain 5XY2 catabolize L-arabinose as well as D-glucose and D-xylose in fermentation
Meyerozyma caribbica
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.08
-
crude enzyme, at pH 7.0 and 30°C
Meyerozyma caribbica
2
-
purified recombinant enzyme, pH 7.0, 40°C
Meyerozyma caribbica
4.9
-
after purification, at pH 7.0 and 30°C
Meyerozyma caribbica
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-sorbitol + NAD+
-
738728
Meyerozyma caribbica
? + NADH + H+
-
-
-
?
D-sorbitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
? + NADH + H+
-
-
-
?
D-sorbitol + NAD+ |
-
738728
Meyerozyma caribbica
D-fructose + NADH + H+
-
-
-
r
D-sorbitol + NAD+ |
-
738728
Meyerozyma caribbica 5XY2
D-fructose + NADH + H+
-
-
-
r
L-arabitol + NAD+
the enzyme also has L-arabitol dehydrogenase activity (20.1% activity compared to xylitol)
738728
Meyerozyma caribbica
L-xylulose + NADH + H+
-
-
-
?
L-arabitol + NAD+
the enzyme also has L-arabitol dehydrogenase activity (20.1% activity compared to xylitol)
738728
Meyerozyma caribbica 5XY2
L-xylulose + NADH + H+
-
-
-
?
additional information
no activity with D-mannitol, erythritol, and D-arabitol. Very low activity with NADP+
738728
Meyerozyma caribbica
?
-
-
-
-
additional information
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol, and L-arabinitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol. No activity with D-mannitol, erythritol, and D-arabinitol
738728
Meyerozyma caribbica
?
-
-
-
-
additional information
no activity with D-mannitol, erythritol, and D-arabitol. Very low activity with NADP+
738728
Meyerozyma caribbica 5XY2
?
-
-
-
-
additional information
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol, and L-arabinitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol. No activity with D-mannitol, erythritol, and D-arabinitol
738728
Meyerozyma caribbica 5XY2
?
-
-
-
-
ribitol + NAD+
-
738728
Meyerozyma caribbica
?
-
-
-
?
ribitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
?
-
-
-
?
ribitol + NAD+
reaction of EC 1.1.1.56, ribitol 2-dehydrogenase
738728
Meyerozyma caribbica
D-ribulose + NADH + H+
-
-
-
?
ribitol + NAD+
reaction of EC 1.1.1.56, ribitol 2-dehydrogenase
738728
Meyerozyma caribbica 5XY2
D-ribulose + NADH + H+
-
-
-
?
xylitol + NAD+
-
738728
Meyerozyma caribbica
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
preferred substrate
738728
Meyerozyma caribbica
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
preferred substrate
738728
Meyerozyma caribbica 5XY2
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
D-xylulose + NADH + H+
-
-
-
?
Subunits
Subunits
Commentary
Organism
homopentamer
; 5 * 39000, SDS-PAGE
Meyerozyma caribbica
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
40
-
;
Meyerozyma caribbica
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
10
55
activity range, inactive at 60°C
Meyerozyma caribbica
45
55
the enzyme partially loses its activity at 45-55°C and also completely loses activity at temperatures greater than 60°C
Meyerozyma caribbica
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
30
45
the enzyme exhibits activities of approximately 81% and 51% after being incubated at 30°C and 35°C, respectively, for 30 min. The enzyme completely loses its activity at temperatures greater than 45°C
Meyerozyma caribbica
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.12
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
3.35
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
4.5
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
8.28
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
18
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
recombinant enzyme
Meyerozyma caribbica
9.5
-
; native enzyme
Meyerozyma caribbica
pH Range
pH Minimum
pH Maximum
Commentary
Organism
4
11
activity range, inactive above or below; the enzyme lost its activity at pH lower than 4.0 and higher than 11.0, corresponding to NAD+ which is unstable at pH values greater than 10.5
Meyerozyma caribbica
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
; preferred cofactor
Meyerozyma caribbica
NADP+
low activity
Meyerozyma caribbica
Cloned(Commentary) (protein specific)
Commentary
Organism
gene xyl2, DNA and amino acid sequence determination and analysis, cloning in Escherichia coli strain JM109, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
Meyerozyma caribbica
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Meyerozyma caribbica
NAD+
preferred cofactor
Meyerozyma caribbica
NADP+
low activity
Meyerozyma caribbica
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
EDTA
-
Meyerozyma caribbica
iodoacetic acid
-
Meyerozyma caribbica
o-phenanthroline
-
Meyerozyma caribbica
Tiron
-
Meyerozyma caribbica
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.1
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
0.11
-
NAD+
at pH 7.0 and 30°C
Meyerozyma caribbica
0.11
-
xylitol
native enzyme, pH 7.0, 30°C
Meyerozyma caribbica
15.4
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
15.8
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
16
-
xylitol
native enzyme, pH 7.0, 30°C
Meyerozyma caribbica
16.1
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
21.2
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
31.1
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
zinc metalloenzyme
Meyerozyma caribbica
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
195000
-
gel filtration
Meyerozyma caribbica
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
xylitol + NAD+
Meyerozyma caribbica
-
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica
preferred substrate
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica 5XY2
preferred substrate
D-xylulose + NADH + H+
-
-
?
xylitol + NAD+
Meyerozyma caribbica 5XY2
-
D-xylulose + NADH + H+
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
DEAEToyopearl 650 M column chromatography, butyl-Toyopearl 650 M column chromatography, MonoQ column chromatography, and Superdex 200 gel filtration
Meyerozyma caribbica
native enzyme by ammonium sulfate fractionation, anion exchange chromatography, hydrophobic interation chromatography, and another different step of anion exchange chromatography, followed by gel filtration. Recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity and anion exchange chromatography
Meyerozyma caribbica
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
strain 5XY2 catabolize L-arabinose as well as D-glucose and D-xylose in fermentation
Meyerozyma caribbica
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.08
-
crude enzyme, at pH 7.0 and 30°C
Meyerozyma caribbica
2
-
purified recombinant enzyme, pH 7.0, 40°C
Meyerozyma caribbica
4.9
-
after purification, at pH 7.0 and 30°C
Meyerozyma caribbica
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-sorbitol + NAD+
-
738728
Meyerozyma caribbica
? + NADH + H+
-
-
-
?
D-sorbitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
? + NADH + H+
-
-
-
?
D-sorbitol + NAD+ |
-
738728
Meyerozyma caribbica
D-fructose + NADH + H+
-
-
-
r
D-sorbitol + NAD+ |
-
738728
Meyerozyma caribbica 5XY2
D-fructose + NADH + H+
-
-
-
r
L-arabitol + NAD+
the enzyme also has L-arabitol dehydrogenase activity (20.1% activity compared to xylitol)
738728
Meyerozyma caribbica
L-xylulose + NADH + H+
-
-
-
?
L-arabitol + NAD+
the enzyme also has L-arabitol dehydrogenase activity (20.1% activity compared to xylitol)
738728
Meyerozyma caribbica 5XY2
L-xylulose + NADH + H+
-
-
-
?
additional information
no activity with D-mannitol, erythritol, and D-arabitol. Very low activity with NADP+
738728
Meyerozyma caribbica
?
-
-
-
-
additional information
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol, and L-arabinitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol. No activity with D-mannitol, erythritol, and D-arabinitol
738728
Meyerozyma caribbica
?
-
-
-
-
additional information
no activity with D-mannitol, erythritol, and D-arabitol. Very low activity with NADP+
738728
Meyerozyma caribbica 5XY2
?
-
-
-
-
additional information
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol, and L-arabinitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol. No activity with D-mannitol, erythritol, and D-arabinitol
738728
Meyerozyma caribbica 5XY2
?
-
-
-
-
ribitol + NAD+
-
738728
Meyerozyma caribbica
?
-
-
-
?
ribitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
?
-
-
-
?
ribitol + NAD+
reaction of EC 1.1.1.56, ribitol 2-dehydrogenase
738728
Meyerozyma caribbica
D-ribulose + NADH + H+
-
-
-
?
ribitol + NAD+
reaction of EC 1.1.1.56, ribitol 2-dehydrogenase
738728
Meyerozyma caribbica 5XY2
D-ribulose + NADH + H+
-
-
-
?
xylitol + NAD+
-
738728
Meyerozyma caribbica
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
preferred substrate
738728
Meyerozyma caribbica
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
preferred substrate
738728
Meyerozyma caribbica 5XY2
D-xylulose + NADH + H+
-
-
-
?
xylitol + NAD+
-
738728
Meyerozyma caribbica 5XY2
D-xylulose + NADH + H+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
homopentamer
5 * 39000, SDS-PAGE
Meyerozyma caribbica
homopentamer
-
Meyerozyma caribbica
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
40
-
-
Meyerozyma caribbica
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
10
55
activity range, inactive at 60°C
Meyerozyma caribbica
45
55
the enzyme partially loses its activity at 45-55°C and also completely loses activity at temperatures greater than 60°C
Meyerozyma caribbica
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
30
45
the enzyme exhibits activities of approximately 81% and 51% after being incubated at 30°C and 35°C, respectively, for 30 min. The enzyme completely loses its activity at temperatures greater than 45°C
Meyerozyma caribbica
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.12
-
xylitol
recombinant enzyme, pH 7.0, 30°C
Meyerozyma caribbica
3.35
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
4.5
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
8.28
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
18
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
recombinant enzyme
Meyerozyma caribbica
9.5
-
-
Meyerozyma caribbica
9.5
-
native enzyme
Meyerozyma caribbica
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
4
11
the enzyme lost its activity at pH lower than 4.0 and higher than 11.0, corresponding to NAD+ which is unstable at pH values greater than 10.5
Meyerozyma caribbica
4
11
activity range, inactive above or below
Meyerozyma caribbica
General Information
General Information
Commentary
Organism
evolution
the enzyme belongs to a medium-chain dehydrogenase/reductase (MDR) superfamily and a subfamily of polyol dehydrogenase, PDH
Meyerozyma caribbica
General Information (protein specific)
General Information
Commentary
Organism
evolution
the enzyme belongs to a medium-chain dehydrogenase/reductase (MDR) superfamily and a subfamily of polyol dehydrogenase, PDH
Meyerozyma caribbica
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.11
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
0.29
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
0.39
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
1.12
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.11
-
L-arabitol
at pH 7.0 and 30°C
Meyerozyma caribbica
0.29
-
ribitol
at pH 7.0 and 30°C
Meyerozyma caribbica
0.39
-
D-sorbitol
at pH 7.0 and 30°C
Meyerozyma caribbica
1.12
-
xylitol
at pH 7.0 and 30°C
Meyerozyma caribbica
Other publictions for EC 1.1.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737895
Zong
Effects of xylitol dehydrogena ...
Scheffersomyces stipitis
Biotechnol. Appl. Biochem.
FEHLT
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2016
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A rare sugar xylitol. Part I: ...
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Annaluru
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Rodrigues
Enhanced xylitol production by ...
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Virginio da Silva
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Ehrensberger
Structure-guided engineering o ...
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Karhumaa
Investigation of limiting meta ...
Saccharomyces cerevisiae
Yeast
22
359-368
2005
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667227
Böer
Characterization of the AXDH g ...
Blastobotrys adeninivorans
Antonie van Leeuwenhoek
87
233-243
2005
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669305
Watanabe
Complete reversal of coenzyme ...
Scheffersomyces stipitis
J. Biol. Chem.
280
10340-10349
2005
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14
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33
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654318
Lima
Effect of acetic acid present ...
Meyerozyma guilliermondii
Appl. Microbiol. Biotechnol.
65
734-738
2004
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656325
Tran
Cloning and expression of a NA ...
Aspergillus oryzae
J. Biosci. Bioeng.
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419-422
2004
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656363
Cortez
Optimized extraction by cetyl ...
Meyerozyma guilliermondii
J. Chromatogr. B
807
47-54
2004
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654212
Jin
Changing flux of xylose metabo ...
Scheffersomyces stipitis
Appl. Biochem. Biotechnol.
105 -108
277-286
2003
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655053
Sugiyama
Cloning of the xylitol dehydro ...
Gluconobacter oxydans
Biosci. Biotechnol. Biochem.
67
584-591
2003
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655221
Nidetzky
Characterization of recombinan ...
Candida sp. HA 167
Chem. Biol. Interact.
143-144
533-542
2003
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656741
Yablochkova
-
The activity of xylose reducta ...
Candida diddensiae, Candida diddensiae F-3, Candida intermedia, Candida parapsilosis, Candida silvanorum, Candida tropicalis, Candida tropicalis Y-456, Kluyveromyces marxianus, Kluyveromyces marxianus Y-488, Meyerozyma guilliermondii, Meyerozyma guilliermondii Y-1017, Pachysolen tannophilus, Scheffersomyces shehatae, Scheffersomyces shehatae Y-1632, Scheffersomyces stipitis
Microbiology
72
414-417
2003
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654229
Alves
Xylose reductase and xylitol d ...
Meyerozyma guilliermondii
Appl. Biochem. Biotechnol.
98-100
403-413
2002
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654231
Mayer
Utilization of xylitol dehydro ...
Candida sp. HA 167
Appl. Biochem. Biotechnol.
98-100
577-589
2002
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655092
Panagiotou
Purification and characterisat ...
Fusarium oxysporum
Biotechnol. Lett.
24
2089-2092
2002
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655894
Godoy de Andrade Rodrigues
Influence of pH on the xylose ...
Meyerozyma guilliermondii
J. Basic Microbiol.
42
201-206
2002
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246423
Ikeuchi
Effect of D-glucose on inducti ...
Candida tropicalis
J. Basic Microbiol.
40
167-175
2000
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246426
Takamizawa
Development of a xylitol biose ...
Candida tropicalis
Can. J. Microbiol.
46
350-357
2000
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246428
Richard
Evidence that the gene YLR070c ...
Saccharomyces cerevisiae
FEBS Lett.
457
135-138
1999
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Kern
Induction of aldose reductase ...
Candida tenuis, Candida tenuis CBS 4435
FEMS Microbiol. Lett.
149
31-37
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246422
Persson
Dual relationships of xylitol ...
Scheffersomyces stipitis
FEBS Lett.
324
9-14
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246425
Singh
Induction and regulation of D- ...
Fusarium oxysporum
Biochem. Int.
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481-488
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3
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246427
Palnitkar
Effect of nitrogen sources on ...
Scheffersomyces shehatae
Can. J. Microbiol.
38
258-260
1992
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246417
Yang
-
Purification and properties of ...
Scheffersomyces shehatae
Appl. Biochem. Biotechnol.
26
197-206
1990
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8
1
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246418
Bolen
Affinity purifications of aldo ...
Pachysolen tannophilus
Appl. Environ. Microbiol.
52
660-664
1986
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Morimoto
-
Purification and properties of ...
Pachysolen tannophilus
J. Ferment. Technol.
64
219-225
1986
3
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11
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1
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2
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3
6
1
1
1
2
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1
1
1
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Doten
Inducible xylitol dehydrogenas ...
Morganella morganii, Providencia stuartii, Serratia marcescens
J. Bacteriol.
162
845-848
1985
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246419
Alizade
Chirality of xylitol-oxidizing ...
Cavia porcellus
FEBS Lett.
67
41-44
1976
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3
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246415
Jakoby
Erythritol dehydrogenase from ...
Klebsiella aerogenes
Biochim. Biophys. Acta
48
26-32
1961
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12
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3
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1
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12
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2
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2
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246416
Chiang
A new pathway of pentose metab ...
Penicillium chrysogenum
Biochem. Biophys. Res. Commun.
3
554-559
1960
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Hickman
A sensitive and stereospecific ...
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J. Biol. Chem.
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11
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1
1
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1
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3
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1
1
1
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1
1
2
11
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1
1
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