BRENDA - Enzyme Database show
show all sequences of 1.1.1.9

Purification of xylitol dehydrogenase and improved production of xylitol by increasing XDH activity and NADH supply in Gluconobacter oxydans

Zhang, J.; Li, S.; Xu, H.; Zhou, P.; Zhang, L.; Ouyang, P.; J. Agric. Food Chem. 61, 2861-2867 (2013)
No PubMed abstract available

Data extracted from this reference:

Application
Application
Commentary
Organism
synthesis
Gluconobacter oxydans strain NH-10 is useful for production of xylitol from D-arabitol via D-xylulose
Gluconobacter oxydans
Cloned(Commentary)
Commentary
Organism
gene xdhA, coexpression of gene xdhA and cofactor regeneration enzyme, i.e. glucose dehydrogenase gene gdh from Bacillus subtilis, in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain JM109
Gluconobacter oxydans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
xylitol + NAD+
Gluconobacter oxydans
-
D-xylulose + NADH + H+
-
-
r
xylitol + NAD+
Gluconobacter oxydans NH-10
-
D-xylulose + NADH + H+
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gluconobacter oxydans
-
isolated from soil, China
-
Gluconobacter oxydans NH-10
-
isolated from soil, China
-
Purification (Commentary)
Commentary
Organism
native enzyme 469fold from sstrain NH-10 by ammonium sulfate fractionation, two different steps of anion exchange chromatography, and gel filtration
Gluconobacter oxydans
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.76
-
purified native enzyme, pH 11.0, 30°C, substrate meso-erythritol
Gluconobacter oxydans
6.74
-
purified native enzyme, pH 11.0, 30°C, substrate D-arabitol
Gluconobacter oxydans
12.89
-
purified native enzyme, pH 11.0, 30°C, substrate D-mannitol
Gluconobacter oxydans
102.5
-
purified native enzyme, pH 11.0, 30°C, substrate xylitol
Gluconobacter oxydans
156.1
-
purified native enzyme, pH 11.0, 30°C, substrate D-sorbitol
Gluconobacter oxydans
180.4
-
purified native enzyme, pH 5.0, 30°C, substrate D-fructose
Gluconobacter oxydans
564
-
purified native enzyme, pH 5.0, 30°C, substrate D-xylulose
Gluconobacter oxydans
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-arabitol + NAD+
-
722437
Gluconobacter oxydans
? + NADH + H+
-
-
-
r
D-arabitol + NAD+
-
722437
Gluconobacter oxydans NH-10
? + NADH + H+
-
-
-
r
D-mannitol + NAD+
-
722437
Gluconobacter oxydans
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NAD+
-
722437
Gluconobacter oxydans NH-10
D-fructose + NADH + H+
-
-
-
r
D-sorbitol + NAD+
-
722437
Gluconobacter oxydans
L-sorbose + NADH + H+
-
-
-
r
D-sorbitol + NAD+
-
722437
Gluconobacter oxydans NH-10
L-sorbose + NADH + H+
-
-
-
r
D-xylulose + NAD+
-
722437
Gluconobacter oxydans
xylitol + NADH + H+
-
-
-
r
meso-erythritol + NAD+
-
722437
Gluconobacter oxydans
? + NADH + H+
-
-
-
r
meso-erythritol + NAD+
-
722437
Gluconobacter oxydans NH-10
? + NADH + H+
-
-
-
r
xylitol + NAD+
-
722437
Gluconobacter oxydans
D-xylulose + NADH + H+
-
-
-
r
xylitol + NAD+
-
722437
Gluconobacter oxydans NH-10
D-xylulose + NADH + H+
-
-
-
r
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
reduction reaction
Gluconobacter oxydans
35
-
oxidation reaction
Gluconobacter oxydans
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
20
55
activity range, profile overview
Gluconobacter oxydans
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
reduction reaction
Gluconobacter oxydans
10.5
11
oxidation reaction
Gluconobacter oxydans
pH Range
pH Minimum
pH Maximum
Commentary
Organism
4
8
reduction reaction, activity range
Gluconobacter oxydans
9
12
oxidation reaction, activity range
Gluconobacter oxydans
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
XDH depends exclusively on NAD+/NADH as cofactors with a relatively low activity
Gluconobacter oxydans
NAD+
-
Gluconobacter oxydans
NADH
-
Gluconobacter oxydans
Application (protein specific)
Application
Commentary
Organism
synthesis
Gluconobacter oxydans strain NH-10 is useful for production of xylitol from D-arabitol via D-xylulose
Gluconobacter oxydans
Cloned(Commentary) (protein specific)
Commentary
Organism
gene xdhA, coexpression of gene xdhA and cofactor regeneration enzyme, i.e. glucose dehydrogenase gene gdh from Bacillus subtilis, in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain JM109
Gluconobacter oxydans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
XDH depends exclusively on NAD+/NADH as cofactors with a relatively low activity
Gluconobacter oxydans
NAD+
-
Gluconobacter oxydans
NADH
-
Gluconobacter oxydans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
xylitol + NAD+
Gluconobacter oxydans
-
D-xylulose + NADH + H+
-
-
r
xylitol + NAD+
Gluconobacter oxydans NH-10
-
D-xylulose + NADH + H+
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme 469fold from sstrain NH-10 by ammonium sulfate fractionation, two different steps of anion exchange chromatography, and gel filtration
Gluconobacter oxydans
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.76
-
purified native enzyme, pH 11.0, 30°C, substrate meso-erythritol
Gluconobacter oxydans
6.74
-
purified native enzyme, pH 11.0, 30°C, substrate D-arabitol
Gluconobacter oxydans
12.89
-
purified native enzyme, pH 11.0, 30°C, substrate D-mannitol
Gluconobacter oxydans
102.5
-
purified native enzyme, pH 11.0, 30°C, substrate xylitol
Gluconobacter oxydans
156.1
-
purified native enzyme, pH 11.0, 30°C, substrate D-sorbitol
Gluconobacter oxydans
180.4
-
purified native enzyme, pH 5.0, 30°C, substrate D-fructose
Gluconobacter oxydans
564
-
purified native enzyme, pH 5.0, 30°C, substrate D-xylulose
Gluconobacter oxydans
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-arabitol + NAD+
-
722437
Gluconobacter oxydans
? + NADH + H+
-
-
-
r
D-arabitol + NAD+
-
722437
Gluconobacter oxydans NH-10
? + NADH + H+
-
-
-
r
D-mannitol + NAD+
-
722437
Gluconobacter oxydans
D-fructose + NADH + H+
-
-
-
r
D-mannitol + NAD+
-
722437
Gluconobacter oxydans NH-10
D-fructose + NADH + H+
-
-
-
r
D-sorbitol + NAD+
-
722437
Gluconobacter oxydans
L-sorbose + NADH + H+
-
-
-
r
D-sorbitol + NAD+
-
722437
Gluconobacter oxydans NH-10
L-sorbose + NADH + H+
-
-
-
r
D-xylulose + NAD+
-
722437
Gluconobacter oxydans
xylitol + NADH + H+
-
-
-
r
meso-erythritol + NAD+
-
722437
Gluconobacter oxydans
? + NADH + H+
-
-
-
r
meso-erythritol + NAD+
-
722437
Gluconobacter oxydans NH-10
? + NADH + H+
-
-
-
r
xylitol + NAD+
-
722437
Gluconobacter oxydans
D-xylulose + NADH + H+
-
-
-
r
xylitol + NAD+
-
722437
Gluconobacter oxydans NH-10
D-xylulose + NADH + H+
-
-
-
r
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
reduction reaction
Gluconobacter oxydans
35
-
oxidation reaction
Gluconobacter oxydans
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
20
55
activity range, profile overview
Gluconobacter oxydans
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.5
-
reduction reaction
Gluconobacter oxydans
10.5
11
oxidation reaction
Gluconobacter oxydans
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
4
8
reduction reaction, activity range
Gluconobacter oxydans
9
12
oxidation reaction, activity range
Gluconobacter oxydans
General Information
General Information
Commentary
Organism
metabolism
bioproduction pathway of xylitol, overview
Gluconobacter oxydans
additional information
XDH depends exclusively on NAD+/NADH as cofactors with a relatively low activity limiting the the overall conversion process, improvement by recombinant expression of enzyme and glucose dehydrogenase cofactor regeneration enzyme
Gluconobacter oxydans
General Information (protein specific)
General Information
Commentary
Organism
metabolism
bioproduction pathway of xylitol, overview
Gluconobacter oxydans
additional information
XDH depends exclusively on NAD+/NADH as cofactors with a relatively low activity limiting the the overall conversion process, improvement by recombinant expression of enzyme and glucose dehydrogenase cofactor regeneration enzyme
Gluconobacter oxydans
Other publictions for EC 1.1.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737895
Zong
Effects of xylitol dehydrogena ...
Scheffersomyces stipitis
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FEHLT
0000
2016
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1
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738725
Qi
Enhanced xylitol production: E ...
Gluconobacter oxydans, Gluconobacter oxydans CGMCC 1.49
J. Biosci. Bioeng.
122
257-262
2016
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1
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4
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10
1
2
1
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2
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738728
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123
20-27
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5
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1
2
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5
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1
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1
1
1
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4
1
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1
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5
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10
1
1
1
1
4
1
1
-
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-
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4
4
738797
Zhang
Integrative expression vectors ...
Scheffersomyces stipitis
J. Ind. Microbiol. Biotechnol.
42
113-124
2015
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1
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1
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6
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1
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1
1
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737866
Yamasaki-Yashiki
Molecular analysis of NAD+-dep ...
Rhizomucor pusillus, Rhizomucor pusillus NBRC 4578
Biosci. Biotechnol. Biochem.
78
1943-1953
2014
-
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1
-
1
-
14
15
-
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1
4
-
5
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1
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13
1
1
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1
6
1
1
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1
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1
1
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1
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14
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15
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1
4
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1
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13
1
1
-
1
6
1
1
-
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1
-
-
1
6
6
738796
Weyda
Point mutation of the xylose r ...
Aspergillus carbonarius
J. Ind. Microbiol. Biotechnol.
41
733-739
2014
-
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-
-
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1
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4
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721913
Mahmud
NAD+-dependent xylitol dehydro ...
Aspergillus oryzae, Aspergillus oryzae KBN616
Biotechnol. Lett.
35
769-777
2013
-
-
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1
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2
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4
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1
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1
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2
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1
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1
-
-
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1
1
-
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722304
Kim
Feasibility of xylose fermenta ...
Scheffersomyces stipitis
FEMS Yeast Res.
13
312-321
2013
-
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1
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-
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1
-
3
-
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722437
Zhang
-
Purification of xylitol dehydr ...
Gluconobacter oxydans, Gluconobacter oxydans NH-10
J. Agric. Food Chem.
61
2861-2867
2013
-
1
1
-
-
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2
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2
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1
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7
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11
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2
1
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2
2
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3
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1
1
3
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1
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7
-
11
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2
1
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2
2
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2
2
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722851
Krahulec
Analysis and prediction of the ...
Saccharomyces cerevisiae
J. Biotechnol.
158
192-202
2012
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710975
Tiwari
Cloning and characterization o ...
Rhizobium etli
Appl. Microbiol. Biotechnol.
87
571-581
2010
-
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1
1
-
-
1
2
-
7
3
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3
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1
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9
1
1
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2
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1
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2
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1
2
1
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1
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2
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7
3
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1
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9
1
1
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2
-
1
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-
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696889
Krahulec
Engineering of a matched pair ...
Candida sp. HA 167
Biotechnol. J.
4
684-694
2009
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1
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1
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1
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1
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1
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1
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1
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699148
Branco
-
Profiles of xylose reductase, ...
Meyerozyma guilliermondii, Meyerozyma guilliermondii FTI 20037
J. Chem. Technol. Biotechnol.
84
326-330
2009
-
1
-
-
-
-
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3
-
3
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1
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1
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1
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3
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6
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1
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1
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699368
Gurpilhares
The behavior of key enzymes of ...
Meyerozyma guilliermondii
J. Ind. Microbiol. Biotechnol.
36
87-93
2009
-
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3
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1
1
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673762
Dmytruk
Overexpression of bacterial xy ...
Ogataea angusta
FEMS Yeast Res.
8
165-173
2008
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700010
Petschacher
-
Altering the coenzyme preferen ...
Candida sp. HA 167
Microb. Cell Fact.
7
0000
2008
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1
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677697
Toivari
Metabolic engineering of Sacch ...
Scheffersomyces stipitis
Appl. Environ. Microbiol.
73
5471-5476
2007
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1
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1
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684592
Karhumaa
High activity of xylose reduct ...
Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
73
1039-1046
2007
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684600
Granstroem
A rare sugar xylitol. Part I: ...
Candida sp. HA 167
Appl. Microbiol. Biotechnol.
74
277-281
2007
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684974
Klimacek
Catalytic mechanism of Zn2+-de ...
Candida sp. HA 167, Ovis aries
Biochem. J.
404
421-429
2007
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1
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6
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2
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686433
Poonperm
-
Production of L-xylulose from ...
Aeribacillus pallidus, Aeribacillus pallidus Y25
Enzyme Microb. Technol.
40
1206-1212
2007
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8
1
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1
4
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1
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687872
Annaluru
Thermostabilization of Pichia ...
Scheffersomyces stipitis
J. Biotechnol.
129
717-722
2007
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6
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688749
Hou
Effect of the reversal of coen ...
Scheffersomyces stipitis
Lett. Appl. Microbiol.
45
184-189
2007
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667268
Ko
Production of xylitol from D-x ...
Candida tropicalis
Appl. Environ. Microbiol.
72
4207-4213
2006
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667284
Mayerhoff
Response surface methodology a ...
Candida mogii
Appl. Microbiol. Biotechnol.
70
761-767
2006
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668350
Rodrigues
Enhanced xylitol production by ...
Meyerozyma guilliermondii
Curr. Microbiol.
53
53-59
2006
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669611
Virginio da Silva
-
Effect of glucose:xylose ratio ...
Meyerozyma guilliermondii
J. Chem. Technol. Biotechnol.
81
1294-1300
2006
-
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670911
Ehrensberger
Structure-guided engineering o ...
Gluconobacter oxydans
Structure
14
567-575
2006
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1
1
1
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4
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663450
Karhumaa
Investigation of limiting meta ...
Saccharomyces cerevisiae
Yeast
22
359-368
2005
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667227
Böer
Characterization of the AXDH g ...
Blastobotrys adeninivorans
Antonie van Leeuwenhoek
87
233-243
2005
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1
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6
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3
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6
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1
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6
1
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1
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669305
Watanabe
Complete reversal of coenzyme ...
Scheffersomyces stipitis
J. Biol. Chem.
280
10340-10349
2005
-
-
1
-
14
-
-
50
-
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2
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1
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1
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2
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33
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2
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2
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14
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50
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1
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2
-
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33
-
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-
-
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654318
Lima
Effect of acetic acid present ...
Meyerozyma guilliermondii
Appl. Microbiol. Biotechnol.
65
734-738
2004
1
1
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656325
Tran
Cloning and expression of a NA ...
Aspergillus oryzae
J. Biosci. Bioeng.
97
419-422
2004
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1
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1
-
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-
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-
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-
-
656363
Cortez
Optimized extraction by cetyl ...
Meyerozyma guilliermondii
J. Chromatogr. B
807
47-54
2004
-
-
-
-
-
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2
1
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2
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1
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1
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-
-
-
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-
-
-
-
654212
Jin
Changing flux of xylose metabo ...
Scheffersomyces stipitis
Appl. Biochem. Biotechnol.
105 -108
277-286
2003
-
1
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-
-
-
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-
-
-
-
655053
Sugiyama
Cloning of the xylitol dehydro ...
Gluconobacter oxydans
Biosci. Biotechnol. Biochem.
67
584-591
2003
-
1
1
-
1
-
3
-
2
-
2
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4
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1
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3
1
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2
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2
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1
1
2
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1
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3
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2
-
2
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1
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2
-
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
655221
Nidetzky
Characterization of recombinan ...
Candida sp. HA 167
Chem. Biol. Interact.
143-144
533-542
2003
-
-
-
-
-
-
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2
2
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4
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1
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5
1
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6
-
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2
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1
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2
2
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1
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5
1
-
-
-
6
-
-
-
1
-
-
-
-
-
-
656741
Yablochkova
-
The activity of xylose reducta ...
Candida diddensiae, Candida diddensiae F-3, Candida intermedia, Candida parapsilosis, Candida silvanorum, Candida tropicalis, Candida tropicalis Y-456, Kluyveromyces marxianus, Kluyveromyces marxianus Y-488, Meyerozyma guilliermondii, Meyerozyma guilliermondii Y-1017, Pachysolen tannophilus, Scheffersomyces shehatae, Scheffersomyces shehatae Y-1632, Scheffersomyces stipitis
Microbiology
72
414-417
2003
-
-
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15
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34
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20
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20
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34
-
-
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-
-
-
-
-
-
-
654229
Alves
Xylose reductase and xylitol d ...
Meyerozyma guilliermondii
Appl. Biochem. Biotechnol.
98-100
403-413
2002
-
1
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4
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-
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-
-
-
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-
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654231
Mayer
Utilization of xylitol dehydro ...
Candida sp. HA 167
Appl. Biochem. Biotechnol.
98-100
577-589
2002
-
-
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1
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1
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-
1
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-
-
-
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-
-
-
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-
-
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655092
Panagiotou
Purification and characterisat ...
Fusarium oxysporum
Biotechnol. Lett.
24
2089-2092
2002
-
-
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1
4
2
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1
2
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1
1
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2
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1
1
2
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4
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2
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1
2
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1
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1
-
3
1
1
-
2
-
-
1
1
-
-
-
-
-
-
-
655894
Godoy de Andrade Rodrigues
Influence of pH on the xylose ...
Meyerozyma guilliermondii
J. Basic Microbiol.
42
201-206
2002
-
1
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1
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246423
Ikeuchi
Effect of D-glucose on inducti ...
Candida tropicalis
J. Basic Microbiol.
40
167-175
2000
-
-
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1
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246426
Takamizawa
Development of a xylitol biose ...
Candida tropicalis
Can. J. Microbiol.
46
350-357
2000
-
-
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2
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1
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1
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1
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246428
Richard
Evidence that the gene YLR070c ...
Saccharomyces cerevisiae
FEBS Lett.
457
135-138
1999
1
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1
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4
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246424
Kern
Induction of aldose reductase ...
Candida tenuis, Candida tenuis CBS 4435
FEMS Microbiol. Lett.
149
31-37
1997
3
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246422
Persson
Dual relationships of xylitol ...
Scheffersomyces stipitis
FEBS Lett.
324
9-14
1993
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246425
Singh
Induction and regulation of D- ...
Fusarium oxysporum
Biochem. Int.
28
481-488
1992
3
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246427
Palnitkar
Effect of nitrogen sources on ...
Scheffersomyces shehatae
Can. J. Microbiol.
38
258-260
1992
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246417
Yang
-
Purification and properties of ...
Scheffersomyces shehatae
Appl. Biochem. Biotechnol.
26
197-206
1990
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246418
Bolen
Affinity purifications of aldo ...
Pachysolen tannophilus
Appl. Environ. Microbiol.
52
660-664
1986
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246421
Morimoto
-
Purification and properties of ...
Pachysolen tannophilus
J. Ferment. Technol.
64
219-225
1986
3
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11
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6
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246420
Doten
Inducible xylitol dehydrogenas ...
Morganella morganii, Providencia stuartii, Serratia marcescens
J. Bacteriol.
162
845-848
1985
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246419
Alizade
Chirality of xylitol-oxidizing ...
Cavia porcellus
FEBS Lett.
67
41-44
1976
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246415
Jakoby
Erythritol dehydrogenase from ...
Enterobacter aerogenes
Biochim. Biophys. Acta
48
26-32
1961
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2
1
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12
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1
12
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246416
Chiang
A new pathway of pentose metab ...
Penicillium chrysogenum
Biochem. Biophys. Res. Commun.
3
554-559
1960
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246414
Hickman
A sensitive and stereospecific ...
Cavia porcellus
J. Biol. Chem.
234
758-761
1959
1
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2
3
1
1
1
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1
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1
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11
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1
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3
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2
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3
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1
1
1
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1
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1
1
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11
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1
1
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