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Literature summary for 1.1.1.88 extracted from

  • Ma, S.M.; Garcia, D.E.; Redding-Johanson, A.M.; Friedland, G.D.; Chan, R.; Batth, T.S.; Haliburton, J.R.; Chivian, D.; Keasling, J.D.; Petzold, C.J.; Lee, T.S.; Chhabra, S.R.
    Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases (2011), Metab. Eng., 13, 588-597.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-mevalonate + CoA + 2 NAD+ Delftia acidovorans
-
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
(R)-mevalonate + CoA + 2 NAD+ Pseudomonas mevalonii
-
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
(R)-mevalonate + CoA + 2 NAD+ Bordetella petrii
-
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r

Organism

Organism UniProt Comment Textmining
Bordetella petrii
-
-
-
Delftia acidovorans
-
-
-
Pseudomonas mevalonii
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7
-
reverse reaction, pH 7.9, 30°C Pseudomonas mevalonii
2.73
-
forward reaction, pH 7.9, 30°C Pseudomonas mevalonii
4.87
-
reverse reaction, pH 7.9, 30°C Delftia acidovorans
11.94
-
forward reaction, pH 7.9, 30°C Delftia acidovorans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mevalonate + CoA + 2 NAD+
-
Delftia acidovorans 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
(R)-mevalonate + CoA + 2 NAD+
-
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
(R)-mevalonate + CoA + 2 NAD+
-
Bordetella petrii 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r

Synonyms

Synonyms Comment Organism
HMG-CoA reductase
-
Delftia acidovorans
HMG-CoA reductase
-
Pseudomonas mevalonii
HMG-CoA reductase
-
Bordetella petrii
NADH-dependent HMG-CoA reductase
-
Delftia acidovorans
NADH-dependent HMG-CoA reductase
-
Pseudomonas mevalonii
NADH-dependent HMG-CoA reductase
-
Bordetella petrii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at, both reaction directions Delftia acidovorans
30
-
assay at, both reaction directions Pseudomonas mevalonii
30
-
assay at, both reaction directions Bordetella petrii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
assay at, both reaction directions Delftia acidovorans
7.9
-
assay at, both reaction directions Pseudomonas mevalonii
7.9
-
assay at, both reaction directions Bordetella petrii

Cofactor

Cofactor Comment Organism Structure
additional information sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, overview Delftia acidovorans
additional information sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, overview Bordetella petrii
additional information sequence comparisons of several species with class II (NAD(H)) and class I (NADP(H)) HMG-CoA reductases for analysis of cofactor binding, specificity-determining residue of HMGR from Pseudomonas mevalonii is D646, overview Pseudomonas mevalonii
NAD+
-
Delftia acidovorans
NAD+
-
Pseudomonas mevalonii
NAD+
-
Bordetella petrii
NADH
-
Delftia acidovorans
NADH
-
Pseudomonas mevalonii
NADH
-
Bordetella petrii

General Information

General Information Comment Organism
additional information sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview Delftia acidovorans
additional information sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview Pseudomonas mevalonii
additional information sequence comparisons of several species with class II and class I HMG-CoA reductases for analysis of cofactor binding, overview Bordetella petrii