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Literature summary for 1.1.1.88 extracted from

  • Slotta, J.; Laschke, M.; Wang, Y.; Schilling, M.; Menger, M.; Thorlacius, H.
    Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury (2009), J. Investig. Med., 57, 645-649.
    View publication on PubMed

Application

Application Comment Organism
medicine in endotoxemic mice, leukocyte infiltration in the liver is significantly elevated. Simvastatin significantly reduces endotoxin-induced hepatocellular damage and apoptosis. Hepatic accumulation of leukocytes is attenuated by simvastatin. Co-administration of mevalonate abolishes the protective effects of simvastatin on endotoxin-provoked increases in serum alanine transferase and serum alanine transferase as well as leukocyte recruitment Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
simvastatin treatment prevents endotoxemic liver injury by inhibiting leukocyte infiltration and hepatocellular apoptosis. The protective effects are dependent on the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
-