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Literature summary for 1.1.1.88 extracted from

  • Yu, Q.; Liu, L.; Wang, Y.
    Expression of low-density lipoprotein receptors and hydroxy methylglutaryl-coenzyme A-reductase in human pterygium (2009), Int. J. Ophthal., 9, 284-285.
No PubMed abstract available

Application

Application Comment Organism
medicine pterygium has an altered metabolism of cholesterol, namely increased LDL-R and HMG-CoA-R mRNAs. Both genes may play important roles in the pathogenesis of pterygium Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
conjunctiva
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Homo sapiens
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pterygium primary and reccurent pterygium Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens mRNA levels of HMG-CoA-R are increased significantly in both primary and recurrent pterygia by 4.2fold and 3.6fold respectively, compared with normal conjunctiva. Concomitantly, there is a significant increase of LDL-R mRNA levels of 4.1fold in primary pterygia and 2.7fold in recurrent pterygium, compared with the control normal conjunctiva up